Topic leaderboard
General methods of organic chemistry
Ranked by the PatentIndex Score — a 1–99 percentile within C07B · public-visibility date · generated 2026
top 25 per window · public-visibility date
Rising· last 2 yrs
Inventors whose newest C07B patents became public in the last 2 years — the current frontier
- 199Stacey Shepard27 patents · 1,120 citations
- 296Ahmed A. Othman34 patents · 595 citations
- 392Mohamed-Eslam F. Mohamed34 patents · 595 citations
- 488Peter T. Mayer22 patents · 395 citations
- 583Jayanthy Jayanth19 patents · 386 citations
- 679Patrick J. Marroum19 patents · 386 citations
- 775Beili Zhang25 patents · 1,085 citations
- 871Ben Klünder33 patents · 553 citations
- 967Pingli Liu16 patents · 409 citations
- 1063Sara S. Hadida Ruah25 patents · 476 citations
- 1158Jason Mccartney17 patents · 444 citations
- 1254Mathew M. Mulhern7 patents · 154 citations
- 1350Fredrik Lars Nordstrom7 patents · 126 citations
- 1446Gillian Moore21 patents · 209 citations
- 1542Hemant Kashinath Patil18 patents · 209 citations
- 1638Aileen L. Pangan16 patents · 241 citations
- 1733Jinwang Xu14 patents · 155 citations
- 1829John Patrick Maxwell14 patents · 155 citations
- 1925Simon Giroux14 patents · 155 citations
- 2021Martin Bohlin17 patents · 247 citations
- 2117Ingvar Ymen11 patents · 235 citations
- 2213Adrian St. Clair Brown8 patents · 118 citations
- 238Peter Lamb6 patents · 116 citations
- 244William P. Gallagher6 patents · 116 citations
- 251Dennis James Hurley14 patents · 252 citations
Active· last 5 yrs
Sustained C07B output across the last 5 years
- 199Stacey Shepard27 patents · 1,120 citations
- 296Martin Trudeau14 patents · 600 citations
- 392Mariusz Krawiec27 patents · 1,308 citations
- 488Ahmed A. Othman34 patents · 595 citations
- 583Mohamed-Eslam F. Mohamed34 patents · 595 citations
- 679Peter T. Mayer22 patents · 395 citations
- 775Jayanthy Jayanth19 patents · 386 citations
- 871Patrick J. Marroum19 patents · 386 citations
- 967Beili Zhang25 patents · 1,085 citations
- 1063Ali Keshavarz-Shokri27 patents · 935 citations
- 1158Ben Klünder33 patents · 553 citations
- 1254Ayman Allian12 patents · 287 citations
- 1350Yuchuan Gong14 patents · 449 citations
- 1446Patrick R. Connelly8 patents · 419 citations
- 1542Adriana Costache7 patents · 378 citations
- 1638Christopher R. Young7 patents · 378 citations
- 1733Patricia Hurter7 patents · 378 citations
- 1829William Rowe7 patents · 378 citations
- 1925Yushi Feng7 patents · 378 citations
- 2021Pingli Liu16 patents · 409 citations
- 2117Akihiro Hashimoto29 patents · 634 citations
- 2213Sara S. Hadida Ruah25 patents · 476 citations
- 238Jason Mccartney17 patents · 444 citations
- 244Erick Goldman13 patents · 273 citations
- 251Norbert Purro13 patents · 273 citations
All-time canon
Career PatentIndex Score in C07B
- 199Lubert Stryer33 patents · 18,862 citations
- 296J. Leighton Read29 patents · 18,080 citations
- 392Michael C. Pirrung29 patents · 18,080 citations
- 488James L. Winkler16 patents · 4,545 citations
- 583Christopher J. Buchko10 patents · 3,646 citations
- 679Debra A. Ross10 patents · 3,646 citations
- 775Lois Aldwin10 patents · 3,646 citations
- 871Jingyue Ju24 patents · 1,469 citations
- 967Yasuhiro Itagaki24 patents · 1,469 citations
- 1063Zengmin Li24 patents · 1,469 citations
- 1158Macdonald Morris13 patents · 3,301 citations
- 1254Chad A. Mirkin37 patents · 4,410 citations
- 1350Robert L. Letsinger35 patents · 4,050 citations
- 1446James J. Storhoff32 patents · 3,707 citations
- 1542Robert Elghanian32 patents · 3,707 citations
- 1638Robert C. Mucic32 patents · 3,707 citations
- 1733Jack W. Szostak7 patents · 1,975 citations
- 1829Robert J. Lipshutz9 patents · 2,951 citations
- 1925Thomas A. Taton29 patents · 2,707 citations
- 2021Mark A. Horn5 patents · 2,311 citations
- 2117Peter F. Heinstein5 patents · 2,311 citations
- 2213Michael S. Urdea5 patents · 2,658 citations
- 238Mohammad Ashty Saleh14 patents · 813 citations
- 244Paul Maes14 patents · 813 citations
- 251Ronald G. Sosnowski11 patents · 1,913 citations
Rising· last 2 yrs
The top-scoring C07B patents made public in the last 2 years
- 199US12344585B2✦ AICrystalline salts of a plasma kallikrein inhibitor6 cites · 202461% earned
- 296US12128033B2✦ AISynthetic methods for preparation of 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1S)-2-cyclo4 cites · 202467% earned
- 392US12006305B2✦ AISalts of obicetrapib and processes for their manufacture and intermediates thereof5 cites · 202472% earned
- 488US12180217B2Compounds and methods for treatment of viral infections3 cites · 202457% earned
- 583US12297226B2Compounds and methods for treatment of viral infections3 cites · 202467% earned
- 679US11905280B12-(benzo[d]oxazol-2-yl)-N'-(picolinoyloxy)acetimidamide as an antimicrobial compound4 cites · 202482% earned
- 775US11958807B2Deuterated tryptamine derivatives and methods of use3 cites · 202452% earned
- 871US12275684B2Methods for making and using endoxifen2 cites · 202449% earned
- 967US12447164B2Method for treating anxiety disorders, headache disorders, and eating disorders with psilo3 cites · 202456% earned
- 1063US12060386B2Compositions and methods for treating CNS disorders3 cites · 202463% earned
- 1158US12365661B2Advantageous benzofuran compositions for mental disorders or enhancement3 cites · 202463% earned
- 1254US12221428B2Use of deuterated empathogens as therapeutic agents2 cites · 202461% earned
- 1350US12521368B2Modulators of TNF-alpha activity1 cites · 202556% earned
- 1446US12458647B2Macrocyclic derivative and use thereof1 cites · 202556% earned
- 1542US12116353B1Crystalline chloro-n-(4-(morpholinomethyl)phenyl)benzamide and crystalline hydrochloride s2 cites · 202467% earned
- 1638US12077545B2Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazi2 cites · 202438% earned
- 1733US12221417B2Salt of omecamtiv mecarbil and process for preparing salt2 cites · 202444% earned
- 1829US12324806B2Method of treating SCLC and managing hepatotoxicity2 cites · 202451% earned
- 1925US12006340B2Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus2 cites · 202453% earned
- 2021US12091431B2Crystals2 cites · 202458% earned
- 2117US11999744B2Crystalline forms of (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[22 cites · 202458% earned
- 2213US11970467B1N′-(2-naphthoyloxy)-2-(benzo[d]oxazol-2-yl)acetimidamide as an antimicrobial compound2 cites · 202461% earned
- 238US12006322B2Substituted pyridines as PARP1 inhibitors2 cites · 202461% earned
- 244US11999730B1AKT1 modulators2 cites · 202461% earned
- 251US11970468B12-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compo2 cites · 202467% earned
Active· last 5 yrs
The top-scoring C07B patents of the last 5 years
- 199US11185535B2✦ AIAmorphous kinase inhibitor formulations and methods of use thereof39 cites · 202178% earned
- 296US11242318B2✦ AIDeuterated tryptamine derivatives and methods of use38 cites · 202174% earned
- 392US11198697B1✦ AIProcesses for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazi29 cites · 202165% earned
- 488US11524964B2Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazi21 cites · 202290% earned
- 583US11512092B2Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazi21 cites · 202290% earned
- 679US11365198B2Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazi25 cites · 202282% earned
- 775US11084780B1Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-24 cites · 202178% earned
- 871US11535625B2Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]-pyrazin-8-yl)-N-(2,219 cites · 202275% earned
- 967US11180517B2Preparation of psilocybin, different polymorphic forms, intermediates, formulations and th22 cites · 202169% earned
- 1063US11453641B2Methods of treating neurofibromatosis with N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-21 cites · 202279% earned
- 1158US11814406B2Compounds and methods for treatment of viral infections11 cites · 202378% earned
- 1254US11063226B1Organic electronic element comprising compound for organic electronic element and an elect21 cites · 202182% earned
- 1350US11471417B2Deuterated N,N-dimethyltryptamine compounds16 cites · 202184% earned
- 1446US11377456B2Crystalline form of Remdesivir16 cites · 202289% earned
- 1542US11597742B2Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f] [1,19 cites · 202181% earned
- 1638US11851438B21′-cyano nucleoside analogs and methods for treatment of viral infections9 cites · 202369% earned
- 1733US11014931B23-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazol18 cites · 202175% earned
- 1829US11358975B2Process for preparing organotin compounds15 cites · 202280% earned
- 1925US11560382B2Organic compounds17 cites · 202175% earned
- 2021US11697660B2Process for preparing organotin compounds11 cites · 202282% earned
- 2117US11685750B2Crystalline forms of IRAK degraders13 cites · 202183% earned
- 2213US10988479B1Morphic forms of trilaciclib and methods of manufacture thereof15 cites · 202174% earned
- 238US11129912B1Radiopharmaceutical and methods12 cites · 202188% earned
- 244US11780848B2Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazi7 cites · 202375% earned
- 251US11465969B2Salts and crystal forms of omecamtiv mecarbil16 cites · 202180% earned
All-time canon
The defining C07B patents of the whole record
- 199US5143854A✦ AILarge scale photolithographic solid phase synthesis of polypeptides and receptor binding s3,709 cites · 199285% earned
- 296US5445934A✦ AIArray of oligonucleotides on a solid substrate3,129 cites · 199584% earned
- 392US5744305A✦ AIArrays of materials attached to a substrate3,038 cites · 199887% earned
- 488US5474796AMethod and apparatus for conducting an array of chemical reactions on a support surface1,844 cites · 199592% earned
- 583US5800992AMethod of detecting nucleic acids1,804 cites · 199888% earned
- 679US5424186AVery large scale immobilized polymer synthesis1,758 cites · 199593% earned
- 775US5605662AActive programmable electronic devices for molecular biological analysis and diagnostics1,613 cites · 199791% earned
- 871US5837832AArrays of nucleic acid probes on biological chips1,445 cites · 199895% earned
- 967US5384261AVery large scale immobilized polymer synthesis using mechanically directed flow paths1,412 cites · 199593% earned
- 1063US6582908B2Oligonucleotides1,335 cites · 200195% earned
- 1158US5510270ASynthesis and screening of immobilized oligonucleotide arrays1,288 cites · 199683% earned
- 1254US5632957AMolecular biological diagnostic systems including electrodes1,244 cites · 199793% earned
- 1350US5556752ASurface-bound, unimolecular, double-stranded DNA1,207 cites · 199689% earned
- 1446US5416016AMethod for enhancing transmembrane transport of exogenous molecules1,154 cites · 199590% earned
- 1542US5412087ASpatially-addressable immobilization of oligonucleotides and other biological polymers on 1,094 cites · 199595% earned
- 1638US5547839ASequencing of surface immobilized polymers utilizing microflourescence detection1,016 cites · 199686% earned
- 1733US5405783ALarge scale photolithographic solid phase synthesis of an array of polymers994 cites · 199582% earned
- 1829US5677195ACombinatorial strategies for polymer synthesis943 cites · 199791% earned
- 1925US5545730AMultifunctional nucleic acid monomer921 cites · 199689% earned
- 2021US5525465AOligonucleotide-polyamide conjugates and methods of production and applications of the sam910 cites · 199695% earned
- 2117US5527681AImmobilized molecular synthesis of systematically substituted compounds823 cites · 199692% earned
- 2213US5552538AOligonucleotides with cleavable sites816 cites · 199689% earned
- 238US5578717ANucleotides for introducing selectably cleavable and/or abasic sites into oligonucleotides792 cites · 199689% earned
- 244US6045996AHybridization assays on oligonucleotide arrays787 cites · 200092% earned
- 251US5639603ASynthesizing and screening molecular diversity755 cites · 199795% earned
Rising· last 2 yrs
Assignees whose newest C07B patents became public in the last 2 years — the current frontier
- 199PURDUE RESEARCH FOUNDATION22 patents · 2,376 citations
- 296INCYTE CORP82 patents · 1,645 citations
- 392VERTEX PHARMA97 patents · 2,115 citations
- 488UNIV TEXAS29 patents · 938 citations
- 583ABBVIE INC67 patents · 912 citations
- 679CELGENE CORP75 patents · 729 citations
- 775CONCERT PHARMACEUTICALS INC59 patents · 489 citations
- 871HARVARD COLLEGE36 patents · 712 citations
- 967BRISTOL MYERS SQUIBB CO103 patents · 727 citations
- 1063HOFFMANN LA ROCHE125 patents · 1,251 citations
- 1158AMGEN INC50 patents · 429 citations
- 1254INTRA CELLULAR THERAPIES INC22 patents · 376 citations
- 1350PFIZER131 patents · 683 citations
- 1446COMPASS PATHFINDER LTD17 patents · 158 citations
- 1542GILEAD SCIENCES INC93 patents · 654 citations
- 1638MERCK PATENT GMBH62 patents · 419 citations
- 1733JANSSEN PHARMACEUTICA NV95 patents · 251 citations
- 1829LILLY CO ELI52 patents · 289 citations
- 1925DEUTERX LLC13 patents · 206 citations
- 2021BOEHRINGER INGELHEIM INT28 patents · 155 citations
- 2117BAYER AG97 patents · 810 citations
- 2213NOVARTIS AG102 patents · 332 citations
- 238EXELIXIS INC16 patents · 103 citations
- 244AKEBIA THERAPEUTICS INC7 patents · 78 citations
- 251THERAVANCE BIOPHARMA R&D IP LLC49 patents · 217 citations
Active· last 5 yrs
Sustained C07B output across the last 5 years
- 199UNIV COLUMBIA38 patents · 2,489 citations
- 296UNIV LELAND STANFORD JUNIOR23 patents · 1,580 citations
- 392PURDUE RESEARCH FOUNDATION22 patents · 2,376 citations
- 488INCYTE CORP82 patents · 1,645 citations
- 583VERTEX PHARMA97 patents · 2,115 citations
- 679UNIV TEXAS29 patents · 938 citations
- 775ABBVIE INC67 patents · 912 citations
- 871CELGENE CORP75 patents · 729 citations
- 967SAMUMED LLC16 patents · 428 citations
- 1063ACHILLION PHARMACEUTICALS INC30 patents · 664 citations
- 1158PHARMACYCLICS LLC14 patents · 273 citations
- 1254MASSACHUSETTS INST TECHNOLOGY51 patents · 1,170 citations
- 1350CONCERT PHARMACEUTICALS INC59 patents · 489 citations
- 1446UNIV CALIFORNIA85 patents · 920 citations
- 1542UNIV MICHIGAN17 patents · 576 citations
- 1638HARVARD COLLEGE36 patents · 712 citations
- 1733BRISTOL MYERS SQUIBB CO103 patents · 727 citations
- 1829HOFFMANN LA ROCHE125 patents · 1,251 citations
- 1925AMGEN INC50 patents · 429 citations
- 2021INTRA CELLULAR THERAPIES INC22 patents · 376 citations
- 2117WARNER LAMBERT CO28 patents · 324 citations
- 2213PFIZER131 patents · 683 citations
- 238COMPASS PATHFINDER LTD17 patents · 158 citations
- 244GILEAD SCIENCES INC93 patents · 654 citations
- 251UNIV SOUTHERN CALIFORNIA12 patents · 237 citations
All-time canon
All-time PatentIndex Score in C07B
- 199AFFYMAX TECH NV24 patents · 20,266 citations
- 296AFFYMETRIX INC88 patents · 22,347 citations
- 392NANOGEN INC34 patents · 7,052 citations
- 488UNIV COLUMBIA38 patents · 2,489 citations
- 583ISOTECHNIKA INC11 patents · 2,532 citations
- 679UNIV LELAND STANFORD JUNIOR23 patents · 1,580 citations
- 775NANOSPHERE INC35 patents · 4,286 citations
- 871CHIRON CORP13 patents · 3,166 citations
- 967GEN HOSPITAL CORP7 patents · 1,696 citations
- 1063PURDUE RESEARCH FOUNDATION22 patents · 2,376 citations
- 1158BIOVAIL LAB INT SRL12 patents · 682 citations
- 1254INCYTE CORP82 patents · 1,645 citations
- 1350SEQUENOM INC8 patents · 1,254 citations
- 1446WELLSTAT THERAPEUTICS CORP13 patents · 612 citations
- 1542VERTEX PHARMA97 patents · 2,115 citations
- 1638AGILENT TECHNOLOGIES INC21 patents · 1,773 citations
- 1733ISIS PHARMACEUTICALS INC30 patents · 1,394 citations
- 1829SOMALOGIC INC7 patents · 615 citations
- 1925UNIV TEXAS29 patents · 938 citations
- 2021ABBVIE INC67 patents · 912 citations
- 2117CELGENE CORP75 patents · 729 citations
- 2213SYMYX TECHNOLOGIES INC11 patents · 531 citations
- 238MOLECULAR DESIGN INT7 patents · 970 citations
- 244EPOCH BIOSCIENCES INC11 patents · 821 citations
- 251SAMUMED LLC16 patents · 428 citations
90–99 field-defining50–89 strong<50 emergingearned by citationsfrom family breadth