Substituted acetyl-coa carboxylase inhibitors

Abstract

The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein G is R 1 , R 2 and R 3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

What is claimed is: 
     
         1 . A compound of Formula (I) 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof, wherein
 G is 
 
       
         
           
           
               
               
           
         
         R 1  is a (C 1 -C 6 )alkyl or (C 3 -C 7 )cycloalkyl; 
         R 2  is indolyl, indazolyl, pyrrolopyridinyl, pyrazolopyridinyl, quinolinyl or benzoimidazolyl; wherein each R 2  group is optionally substituted with one to two substituents independently selected from a cyano, -L-C(O)NR 4 R 5 , -L-NR 4 R 5 , (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy and halo; 
         R 3  is hydrogen or (C 1 -C 3 )alkyl; 
         L is a direct bond or —X(C 1 -C 3 )alkylene; 
         X is a direct bond, O or S; 
         R 4  and R 5  are each independently hydrogen, (C 1 -C 3 )alkyl, (C 3 -C 7 )cycloalkyl or four to seven membered heterocyclyl wherein said (C 1 -C 3 )alkyl, (C 3 -C 7 )cycloalkyl or four to seven membered heterocyclyl is optionally substituted with one to three fluoro or (C 1 -C 3 )alkoxy.