Methods For Assessing, Improving, Or Maintaining Urogenital Health in Postmenopausal Woman

Abstract

This invention relates to methods and kits useful for improving or maintaining urogenital health using an estrogen agonist/antagonist. The methods of treatment are effective for improving or maintaining urogenital health while substantially reducing the concomitant liability of adverse effects associated with estrogen administration. This invention also relates to methods of assessing vaginal health.

1 .- 10 . (canceled) 
   
   
       11 . A method of treating a urinary tract infection, a vaginal yeast or bacterial infection, vaginitis or undesired vaginal spasms by administering to a patient in need thereof a therapeutically effective amount of a compound of formula (IA) 
     
       
         
         
             
             
         
       
     
     wherein G is 
     
       
         
         
             
             
         
       
       R 4  is H, OH, F, or Cl; and B and E are independently selected from CH and N or an optical isomer thereof; or a pharmaceutically acceptable salt thereof. 
     
   
   
       12 . The method of  claim 11  wherein the compound is (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydro-naphthalene-2-ol or a pharmaceutically acceptable salt thereof. 
   
   
       13 . The method of  claim 12  wherein the compound is in the form of a D-tartrate salt. 
   
   
       14 .- 105 . (canceled) 
   
   
       106 . The method of  claim 12  wherein the patient is post-menopausal.