Imidazole compounds for the treatment of neurological disorders

Abstract

The present invention relates to compounds of Formula I wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 and A are as defined. Compounds of Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.

1 .- 19 . (canceled) 
   
   
       20 . A compound selected from:
 N-2-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-N-[1-(2-{[(1-hydroxycyclohexyl)methyl]amino}-11-dimethylethyl)-1H-imidazol-4-yl]-L-norvalinamide;   N-2-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-N-{1-[1-(pyrrolidin-1-ylmethyl)cyclobutyl]-1H-imidazol-4-yl}-L-norvalinamide;   N-2-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-N-[1-(1-{[(22-dimethylpropyl)amino]methyl}cyclobutyl)-1H-imidazol-4-yl]-L-norvalinamide;   N-2-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-N-(1-{1,1-dimethyl-2-[(2-methylbenzyl)amino]-2-oxoethyl}-1H-imidazol-4-yl)-L-norvalinamide;   N-2-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-N-(1-{1-methyl-2-[(tetrahydro-2H-pyran-4-ylmethyl)amino]ethyl}-1H-imidazol-4-yl)-L-norvalinamide; and   N-2-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-N-(1-{2-[(3-methoxypropyl)amino]-1,1-dimethyl-2-oxoethyl}-1H-imidazol-4-yl)-L-norvalinamide; or   a pharmaceutically acceptable salt thereof.   
   
   
       21 . A pharmaceutical composition, comprising a compound according to  claim 20 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 
   
   
       22 . A compound selected from:
 N-2-[(3,5-difluorophenyl)acetyl]-N-{1-[1-(piperidin-1-ylmethyl)cyclobutyl]-1H-imidazol-4-yl}-L-norvalinamide;   N-2-[(3,5-difluorophenyl)acetyl]-N-[1-(1-{[(2,2-dimethylpropyl)amino]methyl}cyclobutyl)-1H-imidazol-4-yl]-L-norvalinamide; and   N-2-[(3,5-difluorophenyl)acetyl]-N-[1-(1-{[(2,2-dimethylpropyl)amino]methyl}cyclobutyl)-1H-imidazol-4-yl]-L-norvalinamide; or   a pharmaceutically acceptable salt thereof.   
   
   
       23 . A pharmaceutical composition, comprising a compound according to  claim 22 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.