Immunogenic LHRH compositions and methods relating thereto

Abstract

The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino acids. The present invention is useful, inter alia, as a prophylactic and/or therapeutic agent for the modification of fertility and behaviour patterns of animals, the achievement of livestock production gains such as increasing growth, decreasing feed conversion ratios or the control of unwanted organoleptic characteristics or the treatment of disorders of the reproductive organs.

1 . A composition for use in eliciting an effective immune response to LHRH said composition comprising a LHRH-diphteria toxoid conjugate adsorbed to an ionic polysaccharide. 
     
     
         2 . The composition according to  claim 1  wherein said ionic polysaccharide is DEAE-dextran. 
     
     
         3 . The composition according to  claim 1  wherein said LHRH is LHRH 2-10 form. 
     
     
         4 . The composition according to  claim 1  wherein LHRH is modified LHRH 2-10 form. 
     
     
         5 . A pharmaceutical composition comprising a LHRH-diphtheria toxoid conjugate adsorbed to an ionic polysaccharide together with one or more pharmaceutically acceptable carriers and/or diluents. 
     
     
         6 . The pharmaceutical composition according to  claim 5  wherein said ionic polysaccharide is DEAE-dextran. 
     
     
         7 . The pharmaceutical composition according to  claim 5  wherein said LHRH is LHRH 2-10 form. 
     
     
         8 . The pharmaceutical composition according to  claim 5  wherein said LHRH is modified LHRH 2-10 form. 
     
     
         9 . A method of eliciting, in an animal, an effective immune response to LHRH said method comprising administering to said animal an effective amount of the composition of  claim 1 .