Ziprasidone suspension

Abstract

Compositions comprising ziprasidone free base or a difficult to wet pharmaceutically acceptable ziprasidone acid addition salt, a polysorbate, and colloidal silicon dioxide form good aqueous suspensions having a useful shelf life and are easily re-suspended if settling occurs.

1 . A composition comprising ziprasidone free base or a pharmaceutically acceptable ziprasidone acid addition salt, water, a polysarbate, a viscosity agent, and colloidal silicon dioxide.  
   
   
       2 . A composition as defined in  claim 1 , wherein said ziprasidone acid addition salt is ziprasidone hydrochloride.  
   
   
       3 . A composition as defined in  claim 1 , wherein said polysorbate is polysorbate 20, 21, 40, 60, 61, 65, 80. 81, 85. or 120.  
   
   
       4 . A composition as defined in  claim 3 , wherein said polysorbate is polysorbate 80.  
   
   
       5 . A composition as defined in  claim 1 , further comprising a taste masking agent selected from alkali metal chlorides and alkaline earth metal chlorides.  
   
   
       6 . A composition as defined in  claim 5 , wherein said alkali metal salt is sodium chloride, potassium chloride, or lithium chloride.  
   
   
       7 . A composition as defined in  claim 6 , wherein said alkali metal salt is sodium chloride.  
   
   
       8 . A composition as defined in  claim 5 , wherein said alkaline earth metal salt is magnesium chloride or calcium chloride.  
   
   
       9 . A composition comprising ziprasidone free base or ziprasidone hydrochloride, a polysorbate, colloidal silicon dioxide, a viscosity agent, and water.  
   
   
       10 . A composition as defined in  claim 9 , wherein said polysorbate is polysorbate 20, 21, 40, 60, 61, 65, 80, 81, 85, or 120.  
   
   
       11 . A composition as defined in  claim 10 , wherein said polysorbale is polysorbate 80.  
   
   
       12 . A composition as defined in  claim 9 , further comprising a taste masking agent selected from alkali metal chlorides and alkaline earth metal chlorides.  
   
   
       13 . A composition as defined in  claim 12 , wherein said alkali metal salt is sodium chloride, potassium chloride, or lithium chloride.  
   
   
       14 . A composition as defined in  claim 13 , wherein said alkali metal salt is sodium chloride.  
   
   
       15 . A composition as defined in  claim 12 , wherein said alkaline earth metal salt is magnesium chloride or calcium chloride.