Bicyclic [3.1.0.] heteroaryl amides as type 1 glycine transport inhibitors

Abstract

The present invention relates to a series of substituted bicyclic[3.1.0]heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R 1 -R 5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.

1 . A compound of Formula I,  
     
       
         
         
             
             
         
       
     
     wherein R 1  represents a heteroaryl selected from the group consisting of: imidazolyl, thiazolyl, pyridyl, oxazolyl, pyrazolyl, triazolyl, oxadiazolyl, quinolinyl, isoxazolyl, pyrroloimidazoyl, and thiadiazole, wherein said heteroaryl is optionally substituted by one or more substituents selected from —OH, —NR 7 R 8 , halogen, (C 1 -C 8 )alkyl, (C 3 -C 10 )cycloalkyl, (C 1 -C 8 )alkoxy, (C 1 -C 12 )alkoxyalkyl, (C 1 -C 8 )hydroxyalkyl, (C 6 -C 14 )aryl and benzyl; 
 R 2 , R 3  and A independently represent H or (C 1 -C 8 )alkyl, wherein said alkyl is optionally substituted by one or more —OH, (C 1 -C 8 )alkoxy, —NR 7 R 8  or halogen;  
 Q represents —(CH 2 ) n —, where n=1, 2, 3 or 4 or —(CH 2 ) m —O—, where m=2, 3 or 4;  
 Z represents (C 6 -C 14 )aryl, (C 1 -C 8 )alkyl or (C 3 -C 8 )cycloalkyl;  
 R 4  and R 5  each independently represent H, halogen, (C 1 -C 8 )alkyl, (C 6 -C 14 )aryl, (C 6 -C 14 )aryloxy, (C 1 -C 8 )alkoxy, (3-10 membered)heterocycloalkyl or (C 3 -C 8 )cycloalkoxy; wherein R 4  and R 5  are optionally substituted by one or more —OH, (C 1 -C 8 )alkoxy, —NR 7 R 8  or halogen;  
 Y represents —R 6 , —(CH 2 ) o —R 6 , —C(R 6 ) 3  or —CH(R 6 ) 2 , wherein o=1, 2 or 3;  
 R 6  represents H, (C 6 -C 14 )aryl, (C 1 -C 10 )alkyl, (C 3 -C 10 )cycloalkyl, (C 5 -C 18 )bicycloalkyl, (C 5 -C 18 )tricycloalkyl, (3-10 membered)heterocycloalkyl, (5-10 membered)heteroaryl, —C(═O)NR 7 R 8 , or —C(═O)OR 7 . wherein said R 6  groups can optionally be substituted with one or more X groups;  
 wherein X≡OH, (C 1 -C 8 )alkoxy, —NR 11 R 12 , —SO 2 R 10 , —C(═O)R 10 , halogen, cyano, (C 1 -C 8 )alkyl, (C 1 -C 10 )alkoxyalkyl, (5-10 membered)heteroaryl, (C 6 -C 14 )aryl, (C 6 -C 14 )aryloxy, benzyl, or (C 1 -C 8 )hydroxyalkyl;  
 wherein R 7  and R 8  independently represent H, (C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl, (5-10 membered)heterocycloalkyl, (C 1 -C 8 )hydroxyalky, (5-10 membered)heteroaryl or (C 1 -C 10 )alkoxyalkyl; wherein R 7  and R 8  may optionally be substituted by one or more X groups;  
 or R 7  and R 8  together with the nitrogen in which they may be attached may form a (3-10 membered)heterocycloalkyl group optionally substituted by one or more X groups;  
 wherein R 10  represents (C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl, (3-10 membered)heterocycloalkyl, (C 1 -C 8 )hydroxyalky, (5-10 membered)heteroaryl or (C 1 -C 10 )alkoxyalkyl;  
 wherein R 11  and R 12  independently represent H, (C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl, (5-10 membered)heterocycloalkyl, (C 1 -C 8 )hydroxyalky, (5-10 membered)heteroaryl or (C 1 -C 10 )alkoxyalkyl;  
 or pharmaceutically acceptable salts, solvates or prodrugs thereof.  
 
   
   
       2 . The compound of  claim 1 , wherein the stereochemistry is defined as in Formula II or Formula III:  
     
       
         
         
             
             
         
       
     
   
   
       3 . The compound of  claim 1 , wherein Z is (C 6 -C 14 )aryl, and R 4  or R 5  are each independently H, halogen, —CF 3 , —OCF 3 , (C 6 -C 14 )aryl or (C 6 -C 14 )aryloxy.  
   
   
       4 . The compound of  claim 1 , wherein R 2 , R 3  and A are hydrogen.  
   
   
       5 . The compound of  claim 1 , wherein Y is a (C 1 -C 6 )alkyl, a (C 3 -C 6 )cycloalkyl, a (3-6 membered)heterocycloalkyl or —CH 2 —(C 3 -C 6 )cycloalkyl; wherein Y is optionally substituted by halogen, OH, —SO 2 R 10 , —C(═O)R 10  or —CH 2 CH 2 CF 3 .  
   
   
       6 . The compound of  claim 3  wherein R 1  is imidazolyl.  
   
   
       7 . A compound having the following formula:  
     
       
         
         
             
             
         
       
       R 2 , R 3  and A independently represent H or (C 1 -C 8 )alkyl, wherein said alkyl is optionally substituted by one or more —OH, (C 1 -C 8 )alkoxy, —NR 7 R 8  or halogen;  
       Q represents —(CH 2 ) n —, where n=1, 2, 3 or 4 or —(CH 2 ) m —O—, where m=2, 3 or 4;  
       Z represents (C 6 -C 14 )aryl, (C 1 -C 8 )alkyl or (C 3 -C 8 )cycloalkyl;  
       R 4  and R 5  each independently represent H, halogen, (C 1 -C 8 )alkyl, (C 6 -C 14 )aryl, (C 6 -C 14 )aryloxy, (C 1 -C 8 )alkoxy, (3-10 membered)heterocycloalkyl or (C 3 -C 8 )cycloalkoxy, wherein R 4  and R 5  are optionally substituted by one or more —OH, (C 1 -C 8 )alkoxy, —NR 7 R 8  or halogen;  
       Y represents —R 6 , —(CH 2 ) o —R 6 , —C(R 6 ) 3  or —CH(R 6 ) 2 , wherein o=1, 2 or 3;  
       R 6  represents H, (C 6 -C 14 )aryl, (C 1 -C 10 )alkyl, (C 3 -C 10 )cycloalkyl, (C 5 -C 18 )bicycloalkyl, (C 5 -C 18 )tricycloalkyl, (3-10 membered)heterocycloalkyl, (5-10 membered)heteroaryl, —C(═O)NR 7 R 8 , or —C(═O)OR 7 , wherein said R 6  may optionally be substituted with one or more X groups;  
       wherein X=—OH, (C 1 -C 8 )alkoxy, —NR 11 R 12 , —SO 2 R 10 , —C(═O)R 10 , halogen, cyano, (C 1 -C 8 )alkyl, (C 1 -C 10 )alkoxyalkyl, (5-10 membered)heteroaryl, (C 6 -C 14 )aryl, (C 6 -C 14 )aryloxy, benzyl, or (C 1 -C 8 )hydroxyalkyl;  
       wherein R 7  and R 8  independently represent H, (C 1 -C 8 )alkyl (C 3 -C 8 )cycloalkyl, (5-10 membered)heterocycloalkyl, (C 1 -C 8 )hydroxyalky, (5-10 membered)heteroaryl or (C 1 -C 10 )alkoxyalkyl; wherein R 7  and R 8  may optionally be substituted by one or more X groups;  
       or R 7  and R 8  together with the nitrogen in which they may be attached may form a (3-10 membered)heterocycloalkyl group optionally substituted by one or more X groups;  
       wherein R 10  represents (C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl, (3-10 membered)heterocycloalkyl, (C 1 -C 8 )hydroxyalky, (5-10 membered)heteroaryl or (C 1 -C 10 )alkoxyalkyl;  
       wherein R 11  and R 12  independently represent H, (C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl, (5-10 membered)heterocycloalkyl, (C 1 -C 8 )hydroxyalky, (5-10 membered)heteroaryl or (C 1 -C 10 )alkoxyalkyl;  
       or pharmaceutically acceptable salts, solvates or prodrugs thereof.  
     
   
   
       8 . The compound of  claim 7 , wherein Z is (C 6 -C 14 )aryl and R 4  or R 5  are each independently H, halogen, —CF 3 , —OCF 3 , (C 6 -C 14 )aryl or (C 6 -C 14 )aryloxy.  
   
   
       9 . The compound of  claim 7 , wherein R 2 , R 3  and A are hydrogen.  
   
   
       10 . The compound of  claim 7 , wherein Y is a (C 1 -C 6 )alkyl, a (C 3 -C 6 )cycloalkyl, a (3-20 membered)heterocycloalkyl or —CH 2 —(C 3 -C 6 )cycloalkyl; wherein Y is optionally substituted by halogen, OH, —SO 2 R 10 , —C(═O)R 10 , or CH 2 CH 2 CF 3 .  
   
   
       11 . The compound of  claim 1 , wherein said compound is selected from the group consisting of: 
 1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-4-fluoro-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-isopropoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-cyclopentyloxy-4-fluoro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2-dimethyl-propoxy)-4-fluoro-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-cyclohexyloxy-4-fluoro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2,2-trifluoro-ethyl)-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-yl methyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopentylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(4-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-cyclopentylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(4-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3,5-dichloro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3,5-dichloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4-fluoro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4-fluoro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-azetidin-3-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(2,4-dichloro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(2,4-dichloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3,4-dichloro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3,4-dichloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-methanesulfonyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-azetidin-3-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-azetidin-3-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-4-fluoro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-[3-(1-methyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4-fluoro-benzyl)-[3-(1-methyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-azetidin-3-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-methyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(1-methyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2,2-trifluoro-ethyl)-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-hydroxy-cyclohexylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(2-chloro-phenyl)-2-hydroxy-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-hydroxy-cyclopentylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3,4-dichloro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3,4-dichloro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(2-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-5-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(2,3-dichloro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(2,4-dichloro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(2-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(2-fluoro-5-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-phenyl-propyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-phenoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-biphenyl-4-ylmethyl-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-phenyl-butyl)-amide;    Pyridine-2-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-biphenyl-3-ylmethyl-amide;    Pyridine-2-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide;    Pyridine-2-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(5-fluoro-2-trifluoromethyl-benzyl)-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    Pyridine-2-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(2-fluoro-5-trifluoromethyl-benzyl)-amide;    Pyridine-2-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-5-trifluoromethyl-benzyl)-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(2-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(2-trifluoromethyl-benzyl)-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[2-(4-chloro-phenyl)-ethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[2-(3-trifluoromethyl-phenyl)-ethyl]-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(2,4-difluoro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[2-(3-chloro-phenyl)-ethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-isobutyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2,2-dimethyl-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(tetrahydro-furan-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(tetrahydro-furan-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1H-imidazol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1H-imidazol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-methyl-butyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(3H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(3-methyl-butyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-ethyl-butyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-isoxazol-3-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-methyl-pentyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-methyl-1H-pyrazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-ethyl-3-methyl-butyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclohexylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-methyl-1H-pyrrol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(3,3-dimethyl-butyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-heptyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-methyl-1H-imidazol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-bicyclo[2.2.1]hept-5-en-2-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(5-methyl-3H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2,4-dimethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(3-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1,5-dimethyl-1H-pyrazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-cyano-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    2-Methyl-3-(6-{[(1-methyl-1H-imidazole-4-carbonyl)-(3-trifluoromethoxy-benzyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hex-3-yl)-propionic acid ethyl ester    1-Methyl-1H-imidazole-4-carboxylic acid(3-phenethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-ethyl-3H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-ethyl-3H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(6-oxo-1,6-dihydro-pyridin-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2,5-dimethyl-2H-pyrazol-3-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-p-tolyl-ethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-ethyl-5-methyl-3H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-ethyl-5-methyl-3H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-methoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-ethyl-hexyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-ethyl-3-methyl-1H-pyrazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-ethyl-3-methyl-1H-pyrazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(5-methoxymethyl-furan-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(3-phenyl-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(3-fluoro-4-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-chloro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-ethyl-5-methyl-1H-pyrazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2,5-difluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-chloro-1-methyl-1H-pyrazol-3-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-chloro-pyridin-3-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1H-benzoimidazol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(3,5-difluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1H-indol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-chloro-thiazol-5-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2,3-difluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1H-indol-5-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(3,5,5-trimethyl-hexyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2,4-difluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-isopropyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-benzo[1,3]dioxol-5-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-pyridin-2-yl-1H-pyrrol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-naphthalen-2-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-benzo[1,3]dioxol-4-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-pyrimidin-2-yl-1H-pyrrol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-naphthalen-1-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[3-(5-methyl-furan-2-yl)-butyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(6,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-benzothiazol-2-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-difluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(4-trifluoromethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-biphenyl-4-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(3-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(3-phenyl-butyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(6-phenoxy-pyridin-3-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-phenoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(2-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-fluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopentylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-[3-(4-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-[3-(1-hydroxy-cyclohexylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-[3-(4-phenoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    Thiazole-4-carboxylic acid(3-phenethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-cyclopentylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-chloro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-fluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-{[ethyl-(2-hydroxy-ethyl)-carbamoyl]-methyl}-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(sec-butyl-methyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(1-methyl-1H-pyrazol-3-ylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopropylcarbamoylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1H-Imidazole-4-carboxylic acid(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1H-Imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(cyclopropylmethyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(tert-butylcarbamoyl-methyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclobutylcarbamoylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(2-methoxy-ethylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(2-methoxy-1-methyl-ethylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopentylcarbamoylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(2-hydroxy-propylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-phenylcarbamoylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(1H-imidazol-2-ylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(isopropylcarbamoyl-methyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(2,2-dimethyl-propylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(pyridin-3-ylcarbamoylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-{[methyl-(3-methyl-pyridin-2-ylmethyl)-carbamoyl]-methyl}-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(2-hydroxy-1,1-dimethyl-ethylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(pyridin-2-ylcarbamoylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(2-methyl-2H-pyrazol-3-ylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-{[(furan-2-ylmethyl)-carbamoyl]-methyl}-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-dimethylcarbamoylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(1-methyl-1H-[1,2,4]triazol-3-ylcarbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclohexylcarbamoylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(2-methyl-pyrrolidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-oxo-2-piperidin-1-yl-ethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(cyclopropylmethyl-methyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-morpholin-4-yl-2-oxo-ethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(3-hydroxy-pyrrolidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(3-hydroxy-pyrrolidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(3-hydroxy-pyrrolidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(ethyl-isopropyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(carbamoylmethyl-methyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(3-methyl-piperidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-oxo-2-thiazolidin-3-yl-ethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(3-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(2-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(3-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-oxo-2-thiomorpholin-4-yl-ethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(2,6-dimethyl-morpholin-4-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(methyl-thiophen-2-ylmethyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(furan-2-ylmethyl-methyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(benzyl-methyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(1,3-dihydro-isoindol-2-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(3,4-difluoro-pyrrolidin-1-yl)-2-oxo-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-{[methyl-(2,2,2-trifluoro-ethyl)-carbamoyl]-methyl}-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(methyl-thiophen-3-ylmethyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[(methyl-phenethyl-carbamoyl)-methyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-{[methyl-(1-pyridin-4-yl-ethyl)-carbamoyl]-methyl}-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-oxo-2-(3-phenyl-pyrrolidin-1-yl)-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-{[(2-methanesulfonyl-ethyl)-methyl-carbamoyl]-methyl}-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-oxo-2-(2-pyridin-4-yl-pyrrolidin-1-yl)-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-[3-(2-hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-[3-(6-phenoxy-pyridin-3-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    Thiazole-4-carboxylic acid[3-(3-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-fluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-methoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-cyclohexylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(3-fluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-phenoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-phenyl-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-cyano-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-biphenyl-4-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(3-cyano-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(4-trifluoromethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    Thiazole-4-carboxylic acid[3-(3,5-dimethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(3-chloro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2,4-dimethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(3-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    Thiazole-4-carboxylic acid[3-(4-ethyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(4-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    Thiazole-4-carboxylic acid[3-(1-methyl-1H-imidazol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(5-methoxymethyl-furan-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(6-oxo-1,6-dihydro-pyridin-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1-ethyl-3-methyl-1H-pyrazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1-methyl-1H-pyrrol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(2-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    Thiazole-4-carboxylic acid(3-furan-3-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1,5-dimethyl-1H-pyrazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1H-pyrrol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(3-phenyl-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1-methyl-1H-pyrazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-fluoro-3-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(5-methyl-3H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-furan-2-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    (6-{[(Thiazole-4-carbonyl)-(3-trifluoromethoxy-benzyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hex-3-yl)-acetic acid butyl ester    Thiazole-4-carboxylic acid[3-(3-fluoro-4-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-ethyl-3H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-ethyl-5-methyl-3H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(tetrahydro-furan-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-p-tolyl-ethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1-ethyl-5-methyl-1H-pyrazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-chloro-pyridin-3-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-isoxazol-3-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1H-indol-3-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    2-Methyl-3-(6-{[(thiazole-4-carbonyl)-(3-trifluoromethoxy-benzyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hex-3-yl)-propionic acid ethyl ester    Thiazole-4-carboxylic acid[3-(5-methyl-2H-pyrazol-3-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-butoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-benzo[1,3]dioxol-5-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-ethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-isopropyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-naphthalen-2-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-benzo[1,3]dioxol-4-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2,3-difluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2,5-difluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-quinolin-7-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-methoxy-3-methyl-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2,4-difluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid{3-[3-(5-methyl-furan-2-yl)-butyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1-pyrimidin-2-yl-1H-pyrrol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(3,5-difluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-difluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-quinolin-8-ylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-butyl-1H-imidazol-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1H-indol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(3-cyano-4-fluoro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1H-indol-5-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-fluoro-4-methoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(1H-benzoimidazol-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(2-chloro-thiazol-5-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid[3-(4-chloro-1-methyl-1H-pyrazol-3-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(1-hydroxy-cyclohexylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(2-hydroxy-indan-2-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-hydroxy-cyclohexylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-hydroxy-cyclopentylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopentylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid cyclohexylmethyl-(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-hydroxy-2-methyl-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopentyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclobutyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-chloro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-cyclohexylmethyl-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(2-hydroxy-cyclopentyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1,5-Dimethyl-1H-pyrazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    5-Methyl-isoxazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    4,5-Dichloro-isothiazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    5-Propyl-isoxazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-isopropoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-cyclopentyloxy-4-fluoro-benzyl)-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2-dimethyl-propoxy)-4-fluoro-benzyl]-amide;    Thiazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-cyclohexyloxy-4-fluoro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3,5-dichloro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-isopropyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Quinoline-2-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Pyridine-2-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    5-Methyl-isoxazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    5-Ethyl-isoxazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Quinoline-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    5-Cyclopropyl-2H-pyrazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1,5-Dimethyl-1H-pyrazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    4-Methyl-1H-imidazole-2-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    5-Propyl-isoxazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    5-Isopropyl-2H-pyrazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-pyrazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    5-Ethyl-2-methyl-2H-pyrazole-3-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    2-Isopropyl-thiazole-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    Thiazole-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    5-Chloro-pyridine-2-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid pentyl-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(2-methyl-butyl)-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(2-ethyl-butyl)-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid cyclopropylmethyl-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid heptyl-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid butyl-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid cyclohexylmethyl-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-chloro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(2-methyl-butyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopentyl-propyl)-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-chloro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-pentyl-amide;    1-Methyl-1H-imidazole-4-carboxylic acid butyl-[3-(4-chloro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-chloro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-cyclopropylmethyl-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-chloro-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(2-ethyl-butyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(tetrahydro-pyran-4-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(4-hydroxy-tetrahydro-pyran-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(4-hydroxy-tetrahydro-pyran-4-ylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(tetrahydro-pyran-4-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-[3-(tetrahydro-pyran-4-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid cyclohexylmethyl-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid cyclohexylmethyl-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    2-Chloro-N-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-N-(1-methyl-1H-imidazol-4-ylmethyl)-3-trifluoromethyl-benzamide;    6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-2-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    3-Chloro-N-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-N-(1-methyl-1H-imidazol-4-ylmethyl)-benzamide;    1-Propyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-(4-Trifluoromethoxy-phenyl)-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Isopropyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(3,3,3-trifluoro-propyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-[2-(4-Trifluoromethoxy-phenyl)-ethyl]-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-propyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Propyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-propyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-(4-Trifluoromethyl-phenyl)-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-propyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Butyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-propyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-(4-Trifluoromethoxy-benzyl)-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-propyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-(4-Trifluoromethoxy-phenyl)-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-propyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Isopropyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-propyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Butyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-(3-Chloro-phenyl)-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Propyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Isopropyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-(4-Trifluoromethoxy-phenyl)-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-pyrazin-2-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1H-benzoimidazol-2-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-methyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-azetidin-3-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-benzyl)-amide;    N-(3-chloro-4-fluorobenzyl)-N-((3-methyl-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl)-1H-imidazole-4-carboxamide; 
 and pharmaceutical salts thereof.  
   
   
   
       12 . The compound of  claim 7 , wherein said compound is selected from: 
 1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-4-fluoro-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-isopropoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-cyclopentyloxy-4-fluoro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2-dimethyl-propoxy)-4-fluoro-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-cyclohexyloxy-4-fluoro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2,2-trifluoro-ethyl)-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopentylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-trifluoromethoxy-benzyl)-[3-(4-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-cyclopentylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(4-trifluoromethoxy-benzyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-cyclopropylmethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3,5-dichloro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3,5-dichloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide Hydrochloride;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4-fluoro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4-fluoro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-azetidin-3-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(2,4-dichloro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(2,4-dichloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3,4-dichloro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3,4-dichloro-benzyl)-(3-ethyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-methanesulfonyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-azetidin-3-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(4-fluoro-3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-azetidin-3-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-4-fluoro-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(4-fluoro-3-trifluoromethyl-benzyl)-[3-(1-methyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4-fluoro-benzyl)-[3-(1-methyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-azetidin-3-yl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-methyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethyl-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-benzyl)-[3-(1-methyl-azetidin-3-yl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2,2-trifluoro-ethyl)-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-[3-(2,2,2-trifluoro-1-trifluoromethyl-ethyl)-benzyl]-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-hydroxy-cyclohexylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid{3-[2-(2-chloro-phenyl)-2-hydroxy-ethyl]-3-aza-bicyclo[3.1.0]hex-6-ylmethyl}-(3-trifluoromethoxy-benzyl)-amide;    1-Methyl-1H-imidazole-4-carboxylic acid[3-(1-hydroxy-cyclopentylmethyl)-3-aza-bicyclo[3.1.0]hex-6-ylmethyl]-(3-trifluoromethoxy-benzyl)-amide; 
 and pharmaceutical salts thereof.  
   
   
   
       13 . A pharmaceutical composition for treating a disorder or condition selected from psychosis, schizophrenia, conduct disorder, disruptive behavior disorder, bipolar disorder, psychotic episodes of anxiety, anxiety associated with psychosis, psychotic mood disorders; behavioral manifestations of mental retardation, conduct disorder and autistic disorder; movement disorders associated with Tourette's syndrome, akinetic-rigid syndrome, movement disorders associated with Parkinson's disease, tardive dyskinesia and other drug induced and neurodegeneration based dyskinesias; attention deficit hyperactivity disorder; cognitive disorders and memory disorders in a mammal, comprising a compound of formula I according to  claim 1  or a pharmaceutically acceptable salt thereof, in an amount that is effective for treating such disorder or condition.  
   
   
       14 . A pharmaceutical composition for treating central nervous system disorders, cognitive disorders, schizophrenia, dementia and other disorders in a mammal, comprising a compound of formula I according to  claim 1  and at least one anti-psychotic selected from the group consisting of: Ziprasidone (Geodon), Clozapine, Molindone, Loxapine, Pimozide, Risperidone, Olanzapine, Remoxipride, Sertindole, Amisulpride, Quetiapine, prochlorperazine, Fluphenazine, Trifluoroperazine, Thioridazine, Haloperidol, Chloropromazine, Flupentixol, and Pipotiazine  
   
   
       15 . A method of treating a disorder or condition selected from psychosis, schizophrenia, conduct disorder, disruptive behavior disorder, bipolar disorder, psychotic episodes of anxiety, anxiety associated with psychosis, psychotic mood disorders; behavioral manifestations of mental retardation, conduct disorder and autistic disorder; movement disorders associated with Tourette's syndrome, akinetic-rigid syndrome, movement disorders associated with Parkinson's disease, tardive dyskinesia and other drug induced and neurodegeneration based dyskinesias; attention deficit hyperactivity disorder; cognitive disorders and memory disorders in a mammal, including a human, comprising administering to a mammal in need of such treatment an amount of a compound of formula I according to  claim 1 , or a pharmaceutically acceptable salt thereof, that is effective in treating such condition or disorder.  
   
   
       16 . A method of treating a disorder or condition selected from psychosis, schizophrenia, conduct disorder, disruptive behavior disorder, bipolar disorder, psychotic episodes of anxiety, anxiety associated with psychosis, psychotic mood disorders; behavioral manifestations of mental retardation, conduct disorder and autistic disorder; movement disorders associated with Tourette's syndrome, akinetic-rigid syndrome, movement disorders associated with Parkinson's disease, tardive dyskinesia and other drug induced and neurodegeneration based dyskinesias; attention deficit hyperactivity disorder; cognitive disorders and memory disorders in a mammal, including a human, comprising administering to a mammal in need of such treatment an amount of a compound of formula I according to  claim 1  and at least one anti-psychotic selected from the group consisting of: Ziprasidone (Geodon), Clozapine, Molindone, Loxapine, Pimozide, Risperidone, Olanzapine, Remoxipride, Sertindole, Amisulpride, Quetiapine, Prochlorperazine, Fluphenazine, Trifluoroperazine, Thioridazine, Haloperidol, Chloropromazine, Flupentixol and Pipotiazine.