Compositions comprising pregnancy specific glycoproteins and methods of use thereof

Abstract

The present invention relates to methods of treating a subject suffering from or at risk of suffering from graft versus host disease (GvHD) comprising administering a therapeutically effective amount of at least one of pregnancy specific glycoprotein 1 (PSG1) or PSG9 to a subject in need thereof.

What is claimed is: 
     
       1. A method of treating a human mammalian subject suffering from graft versus host disease (GvHD) comprising administering to the human mammalian subject a therapeutically effective amount of at least one peptide selected from the group consisting of:
 (a) a peptide comprising the amino acid sequence of SEQ ID NO: 2, and 
 (b) a peptide comprising the amino acid sequence of SEQ ID NO: 4. 
 
     
     
       2. The method of  claim 1 , wherein the at least one peptide is a peptide consisting of the amino acid sequence of SEQ ID NO:2. 
     
     
       3. The method of  claim 1 , wherein the at least one peptide is a peptide consisting of the amino acid sequence of SEQ ID NO:4. 
     
     
       4. The method of  claim 1 , wherein the route of administration of the peptide is intravascular injection, intraperitoneal injection, intramuscular injection, nasal administration or oral administration.