USRE47428EActiveUtility

Modulators of methyl modifying enzymes, compositions and uses thereof

69
Assignee: CONSTELLATION PHARMACEUTICALS INCPriority: Feb 10, 2012Filed: Jan 24, 2018Granted: Jun 11, 2019
Est. expiryFeb 10, 2032(~5.6 yrs left)· nominal 20-yr term from priority
Inventors:Brian K. AlbrechtJames E. AudiaLes A. DakinVictor S. GehlingJean-Christophe HarmangeChristopher G. NasveschukRishi G. Vaswani
A61P 35/00A61P 43/00A61P 13/10A61P 13/12A61P 11/00A61P 15/00A61P 17/00A61P 25/00A61P 13/08A61P 1/16A61P 1/04C07D 409/06C07D 401/14C07D 417/14C07D 405/14C07D 471/04A61K 31/4545C07D 487/04C07D 401/12C07D 417/04
69
PatentIndex Score
0
Cited by
163
References
4
Claims

Abstract

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A compound of the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
       2. The compound of  claim 1 , wherein the compound is of the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
       3. A pharmaceutical composition comprising a compound of the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. 
       
     
     
       4. The pharmaceutical composition of  claim 3 , wherein the compound is of the formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof.

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