Compositions comprising Lactobacillus plantarum strains in combination with tannin and new Lactobacillus plantarum strains

Abstract

The invention refers to a composition comprising one or more tannase-producing strains of Lactobacillus having the ability to adhere to the human intestinal mucosa in combination with tannin. New tannase-producing strains of Lactobacillus plantarum are a.

The invention claimed is: 
     
       1. A composition comprising:
 (a) one or more isolated tannase-producing strains of Lactobacillus plantarum; and   (b) tannin;   wherein said one or more isolated tannase-producing strains of Lactobacillus plantarum are selected from the group consisting of: Lactobacillus plantarum strain HEAL 9, which is deposited as DSM 15312; Lactobacillus plantarum strain HEAL 19, which is deposited as DSM 15313; Lactobacillus plantarum strain HEAL 99, which is deposited as DSM 15316; and combinations thereof.   
     
     
       2. The composition according to  claim 1 , wherein said composition further comprises a carrier. 
     
     
       3. The composition according to  claim 1  which is a food composition. 
     
     
       4. The composition according to  claim 1  which is a pharmaceutical composition. 
     
     
       5. A isolated tannase-producing strain of Lactobacillus plantarum, wherein said isolated tannase-producing strain of Lactobacillus plantarum is selected from the group consisting of: Lactobacillus plantarum strain HEAL 9, which is deposited as DSM 15312; Lactobacillus plantarum strain HEAL 19, which is deposited as DSM 15313; and Lactobacillus plantarum strain HEAL 99, which is deposited as DSM 15316. 
     
     
       6. The isolated tannase-producing strain according to  claim 5 , wherein said isolated tannase-producing strain is Lactobacillus plantarum strain HEAL 9, which is deposited as DSM 15312. 
     
     
       7. The isolated tannase-producing strain according to  claim 5 , wherein said isolated tannase-producing strain is Lactobacillus plantarum strain HEAL 19, which is deposited as DSM 15313. 
     
     
       8. The isolated tannase-producing strain according to  claim 5 , wherein said isolated tannase-producing strain is Lactobacillus plantarum strain HEAL 99, which is deposited as DSM 15316. 
     
     
       9. A medicament for prophylactic or curative treatment of cardiovascular diseases, diabetes, inflammatory bowel diseases (IBD), irritable bowel syndrome (IBS), gastrointestinal infections, cancer, Alzheimer's disease or diseases with an autoimmune origin, wherein said medicament comprises:
 (a) one or more isolated tannase-producing strains of Lactobacillus plantarum having the ability to adhere to the human intestinal mucosa; and   (b) tannin;   wherein said one or more isolated tannase-producing strains of Lactobacillus plantarum are selected from the group consisting of: Lactobacillus plantarum strain HEAL 9, which is deposited as DSM 15312; Lactobacillus plantarum strain HEAL 19, which is deposited as DSM 15313; Lactobacillus plantarum strain HEAL 99, which is deposited as DSM 15316; and combinations thereof.   
     
     
       10. A composition for the preservation of food comprising:
 (a) one or more isolated tannase-producing strains of Lactobacillus plantarum having the ability to adhere to the human intestinal mucosa; and   (b) tannin;   wherein said one or more isolated tannase-producing strains of Lactobacillus plantarum are selected from the group consisting of: Lactobacillus plantarum strain HEAL 9, which is deposited as DSM 15312; Lactobacillus plantarum strain HEAL 19, which is deposited as DSM 15313; Lactobacillus plantarum strain HEAL 99, which is deposited as DSM 15316; and combinations thereof.   
     
     
       11. A food product comprising:
 (a) one or more isolated tannase-producing strains of Lactobacillus plantarum having the ability to adhere to the human intestinal mucosa; and   (b) tannin;   wherein said one or more isolated tannase-producing strains of Lactobacillus plantarum are selected from the group consisting of: Lactobacillus plantarum strain HEAL 9, which is deposited as DSM 15312; Lactobacillus plantarum strain HEAL 19, which is deposited as DSM 15313; Lactobacillus plantarum strain HEAL 99, which is deposited as DSM 15316; and combinations thereof.   
     
     
       12. The composition according to  claim 2  which is a food composition. 
     
     
       13. The composition according to  claim 2  which is a pharmaceutical composition. 
     
     
       14. A method for prevention of ischemia and/or reperfusion injury in the colon and small intestine in a mammal, comprising administering to an individual in need thereof a combination of a tannin and a tannase-producing strain of Lactobacillus plantarum having the ability to adhere to the human intestinal mucosa, wherein the tannase-producing strain of Lactobacillus plantarum is selected from the group consisting of Lactobacillus plantarum 299, which is deposited as DSM 6595, Lactobacillus plantarum 299v, which is deposited as DSM 9843, and combinations thereof, and wherein the tannin is administered in an amount of from about 500 mg to 1000 mg per day.  
     
     
       15. A method for prevention of ischemia and/or reperfusion injury in cecum and ileum tissue in a mammal, comprising administering to an individual in need thereof a combination of a tannin and a tannase-producing strain of Lactobacillus plantarum having the ability to adhere to the human intestinal mucosa, wherein the tannase-producing strain of Lactobacillus plantarum is selected from the group consisting of Lactobacillus plantarum 299, which is deposited as DSM 6595, Lactobacillus plantarum 299v, which is deposited as DSM 9843, and combinations thereof, and wherein the tannin is administered in an amount of from about 500 mg to 1000 mg per day.  
     
     
       16. The method of claim 14, wherein the tannase-producing strain of Lactobacillus plantarum is administered in a composition that is a non-fermented composition.  
     
     
       17. The method of claim 15, wherein the tannase-producing strain of Lactobacillus plantarum is administered in a composition that is a non-fermented composition.  
     
     
       18. The method of claim 14, wherein the method comprises administration of the combination of a tannin and a tannase-producing strain of Lactobacillus plantarum for at least 6 days.  
     
     
       19. The method of claim 15, wherein the method comprises administration of the combination of a tannin and a tannase-producing strain of Lactobacillus plantarum for at least 6 days.  
     
     
       20. The method of claim 16, wherein the method comprises administration of the combination of a tannin and a tannase-producing strain of Lactobacillus plantarum for at least 6 days.  
     
     
       21. The method of claim 17, wherein the method comprises administration of the combination of a tannin and a tannase-producing strain of Lactobacillus plantarum for at least 6 days.  
     
     
       22. The method of claim 14, wherein the mammal is in need due to an anticipated or actual injury to the colon and/or small intestine.  
     
     
       23. The method of claim 15, wherein the mammal is in need due to an anticipated or actual injury to the cecum and/or ileum tissue.  
     
     
       24. The method of claim 16, wherein the mammal is in need due to an anticipated or actual injury to the colon and/or small intestine.  
     
     
       25. The method of claim 17, wherein the mammal is in need due to an anticipated or actual injury to the cecum and/or ileum tissue.  
     
     
       26. The method of claim 18, wherein the mammal is in need due to an anticipated or actual injury to the colon and/or small intestine.  
     
     
       27. The method of claim 19, wherein the mammal is in need due to an anticipated or actual injury to the cecum and/or ileum tissue.  
     
     
       28. The method of claim 20, wherein the mammal is in need due to an anticipated or actual injury to the colon and/or small intestine.  
     
     
       29. The method of claim 21, wherein the mammal is in need due to an anticipated or actual injury to the cecum and/or ileum tissue.