Strains of bacteria and pharmaceutical composition containing one or more of such strains and use of same for preventing and treating diseases associated with or caused by altered metabolism of bile acids

Abstract

Strains of bacteria characterized by exhibiting: (a) a 7α-dehydroxylase activity of less than 50%, and (b) bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.

1. A biologically pure gram-positive bacteria strain characterized by exhibiting:
 (a) a 7α-dehydroxylase activity of less than 50%, and  
 (b) a bile acid deconjugation activity of less than 50%, and  
 belonging to a species selected from Streptococcus thermophilus and Lactobacillus bulgaricus, wherein said strain modifies bile acid metabolism.  
 
     
     
       2. The biologically pure strain of  claim 1 , wherein the bacteria strain is Streptococcus thermophilus YS 52, deposited with the CNCM, Collection Nationale de Cultures de Microorganismes, Institut Pasteur, under the accession number I-1670. 
     
     
       3. The biologically pure strain of  claim 1 , wherein the bacteria strain is Streptococcus thermophilus YS 46, deposited with the CNCM, Collection Nationale de Cultures de Microorganismes, Institut Pasteur, under the accession number I-1668. 
     
     
       4. The biologically pure strain of  claim 1 , wherein the bacteria strain is Streptococcus thermophilus YS 48, deposited with the CNCM, Collection Nationale de Cultures de Microorganismes, Institut Pasteur, under the accession number I-1669. 
     
     
       5. The biologically pure strain of  claim 1 , wherein the bacteria strain is Lactobacillus bulgaricus LB 1 deposited with the CNCM, Collection Nationale de Cultures de Microorganismes, Institut Pasteur, under the accession number I-1664. 
     
     
       6. The biologically pure strain of  claim 1 , wherein the bacteria strain is Lactobacillus bulgaricus LB 3 deposited with the CNCM, Collection Nationale de Cultures de Microorganismes, Institut Pasteur, under the accession number I-1665. 
     
     
       7. The biologically pure strain of  claim 1 , wherein the bacteria strain is Lactobacillus bulgaricus LB 7 deposited with the CNCM, Collection Nationale de Cultures de Microorganismes, Institut Pasteur, under the accession number I-1666. 
     
     
       8. The biologically pure strain of  claim 1 , wherein the bacteria strain is Lactobacillus bulgaricus LB 77 deposited with the CNCM, Collection Nationale de Cultures de Microorganismes, Institut Pasteur, under the accession number I-1667. 
     
     
       9. The biologically pure strain of  claim 1 , wherein the bacteria strain has a 7α-dehydroxylase activity of less than 25%. 
     
     
       10. The biologically pure strain of  claim 1 , wherein the bacteria strain has a bile acid deconjugation activity of less than 25%. 
     
     
       11. The biologically pure strain of  claim 1 , wherein the bacteria strain has a 7α-dehydroxylase activity of less than 25% and a bile acid deconjugation activity of less than 50%.