Enteral dietary compositions comprising a mixture of live lactic bacteria consisting of Streptococcus thermophilus, Bifidobacterium longum and Bifidobacterium infantis

Abstract

Enteral compositions containing a mixture of live lactic bacteria consisting of Streptococcus thermophilus, Bifidobacterium longum and Bifidobacterium infantis , each at a concentration equal to or greater than 1×10 11 CFU per gram, are useful as adjuncts for enteral formulations and as oral nutritional supplements. The compositions can be administered before, during or at the end of an enteral formulation administration. The compositions can be administered separately or mixed with the enteral formulation. The compositions can also be employed at the end of the daily administration in order to prevent the colonization of the enteral tube by the other pathogens. The compositions can also be used as supplement to any liquid, creamy or pasty foodstuff.

1. An enteral dietary composition, comprising:
 a mixture of live lactic acid bacteria consisting of  Streptococcus thermophilus, Bifidobacterium longum  and  Bifidobacterium infantis , wherein the  Streptococcus thermophilus  concentration is at least 1×10 11  CFU per gram, the  Bifidobacterium longum  concentration is at least 1×10 11  CFU per gram, and the  Bifidobacterium infantis  concentration is at least 1×10 10  CFU per gram, each concentration based on the total composition.  
 
     
     
       2. The composition of  claim 1 , wherein the  Streptococcus thermophilus  concentration is 1×10 11  to 1×10 14  CFU per gram,  Bifidobacterium longum  concentration is 1×10 10  to 1×10 14  CFU per gram, and  Bifidobacterium infantis  concentration is 1×10 10  to 1×10 13  CFU per gram, each concentration based on the total composition. 
     
     
       3. The composition of  claim 1 , which is a liquid. 
     
     
       4. The composition of  claim 1 , which is a capsule. 
     
     
       5. A method for stimulating the immune system or modifying the composition of human intestinal flora in vivo, comprising:
 (a) preparing a composition containing a mixture of live lactic acid bacteria, said mixture consisting of  Streptococcus thermophilus, Bifidobacterium longum  and  Bifidobacterium infantis , wherein the  Streptococcus thermophilus  concentration is at least 1×10 11  CFU per gram wherein the  Bifidobacterium longum  concentration is at least 1×10 11  CFU per gram, and the  Bifidobacterium infantis  concentration is at least 1×10 10  CFU per gram, each concentration based on the total composition; and  
 (b) enterally administering the composition of (a) to a subject in need thereof, optionally mixed with a carrier.  
 
     
     
       6. A method for ameliorating diarrhea or intestinal disturbances in a patient in an enteral or parenteral diet feeding program, comprising:
 (a) preparing a composition containing a mixture of live lactic acid bacteria consisting of  Streptococcus thermophilus, Bifidobacterium longum  and  Bifidobacterium infantis , wherein the  Streptococcus thermophilus  concentration is at least 1×10 11  CFU per gram, the  Bifidobacterium longum  concentration is at least 1×10 11  CFU per gram, and the  Bifidobacterium infantis  concentration is at least 1×10 10  CFU per gram, each concentration based on the total composition, and  
 (b) administering the composition of (a) to said patient, optionally mixed with a carrier.