Medicaments

Abstract

Pharmaceutical compositions comprising effective amounts of salmeterol (and a physiologically acceptable salt thereof) and fluctuations propionate as a combined preparation for simultaneous, sequential or separate administration by inhalation in the treatment of respiratory disorders.

1. A pharmaceutical composition comprising effective amounts of salmeterol or a physiologically acceptable salt thereof and fluticasone propionate as a combined preparation for simultaneous, sequential or separate  administration by inhalation in the treatment of respiratory disorders. 
     
     
       2. A composition as claimed in  claim 1 , wherein salmeterol is present as its 1-hydroxy-2-naphthalenecarboxylate salt. 
     
     
       3. A composition as claimed in  claim 1  presented in the form of a metered dose inhaler or a metered dry powder composition. 
     
     
       4. A composition as claimed in  claim 1  in dosage unit form containing 25-100 μg of salmeterol or a physiologically acceptable salt thereof and 25-500 μg of fluticasone propionate per dosage unit. 
     
     
       5. A composition as claimed in  claim 2  presented in the form of a metered dose inhaler or a metered dry powder composition. 
     
     
       6. A composition as claimed in  claim 2  in dosage unit form comprising 25-100 μg of the 1-hydroxy-2-naphthalenecarboxylate salt of salmeterol and 25-500 μg of fluticasone propionate per dosage unit. 
     
     
       7. A composition as claimed in  claim 6  presented in the form of a metered dose inhaler or a metered dry powder composition. 
     
     
       8. The use of salmeterol or a physiologically acceptable salt thereof and fluticasone propionate in the manufacture of pharmaceutical compositions as combined preparations for simultaneous, sequential or separate administration of salmeterol and fluticasone propionate by inhalation in the treatment of respiratory disorders. 
     
     
       9. A method of treating respiratory disorders which comprises the simultaneous, sequential or separate administration by inhalation of effective amounts of salmeterol or a physiologically acceptable salt thereof and fluticasone propionate. 
     
     
       10. A method as claimed in  claim 9  wherein the salmeterol or a physiologically acceptable salt thereof and the fluticasone propionate are administered on a twice daily basis. 
     
     
       11. A method as claimed in  claim 10  wherein the effective amount of salmeterol or a physiologically acceptable salt thereof 50-200 μg per day and the effective amount of fluticasone propionate is 50-1000 μg per day.