Pharmaceutical compositions containing lactobacilli for treatment of vaginal infections and related method

Abstract

Use of an association of lactobacilli for preparation of a pharmaceutical composition for treatment of vaginosis and vaginitis. Said bacteria association comprises the Lactobacillus brevis and Lactobacillus salivarius subs. salicinius species, possibly in combination with one or more species selected from Lactobacillus salivarius subs. salivarius, Lactobacillus jensenii, Lactobacillus catenaforme, Lactobacillus minutus and Lactobacillus gasseri. A pharmaceutical composition comprising said association of lactobacilli adapted for treatment of vaginosis and vaginitis. A method of treating vaginosis and vaginitis based on administration of said pharmaceutical composition.

1. A composition comprising lactobacilli of the Lactobacillus brevis and Lactobacillus salivarius subs. salicinius species, in the form of pessaries or vaginal tablets comprising at least two layers, both layers containing said species of lactobacilli, in bound form, so that the release velocity of bacteria of the outermost layer is greater than the release velocity of bacteria of the innermost layer. 
     
     
       2. The composition as claimed in  claim 1 , wherein said composition further comprises one or more species of lactobacilli selected from Lactobacillus salivarius subs. salivarius, Lactobacillus jensenii, Lactobacillus catenaforme, Lactobacillus minutus and Lactobacillus gasseri. 
     
     
       3. The composition as claimed in  claim 2 , wherein said lactobacilli consist of the Lactobacillus brevis, Lactobacillus salivarius subs. salicinius and Lactobacillus gasseri species. 
     
     
       4. The composition as claimed in  claim 1 , wherein said lactobacilli are present at a concentration of 10 7  to 10 13  CFU/g. 
     
     
       5. A method of treatment of a vaginal infection, comprising administering through the vagina a composition comprising lactobacilli of the Lactobacillus brevis and Lactobacillus salivarius subs. salicinius species, in the form of pessaries or vaginal tablets comprising at least two layers, both layers containing said species of lactobacilli, in bound form, so that the release velocity of bacteria of the outermost layer is greater than the release velocity of bacteria of the innermost layer. 
     
     
       6. The method of  claim 5 , said composition further comprises one or more species of lactobacilli selected from Lactobacillus salivarius subs. salivarius, Lactobacillus jensenii, Lactobacillus catenaforme, Lactobacillus minutus and Lactobacillus gasseri. 
     
     
       7. The method of  claim 6 , wherein said lactobacilli consist of the Lactobacillus brevis, Lactobacillus salivarius subs. salicinius and Lactobacillus gasseri species. 
     
     
       8. The method of  claim 5 , wherein said lactobacilli are present at a concentration of 10 7  to 10 13  CFU/g.