Antipsoriatic compositions, method of making, and method of using

Abstract

A psoriasis treatment composition derived from the plant Asphodelus Microcarpus includes 3-methylanthralin, chrysophanol, aloe-emodin, aloe-emodin monoacetate, and/or derivatives thereof. The composition is prepared by extracting a liquid from the Asphodelus Microcarpus root and mixing the liquid with acetic acid. A method of treatment includes applying the composition to an affected area of skin at a frequency sufficient to effect an alleviation of symptoms, typically once per day for 14-56 days.

1. A composition for the treatment of psoriasis produced by the step comprising mixing together effective amounts of 3-methylanthralin, chrysophanol, aloe-emodin and aloe-emodin monoacetate. 
     
     
       2. The composition recited in  claim 1 , further comprising a derivative of at least one of the compounds 3-methylanthralin, chrysophanol, aloe-emodin, and aloe-emodin monoacetate. 
     
     
       3. A method for treating psoriasis comprising the steps of:
 mixing together 3-methylanthralin, chrysophanol, aloe-emodin, and aloe-emodin monoacetate; and  
 applying the mixture to an area of skin affected by psoriasis with sufficient frequency to effect an alleviation of psoriatic symptoms.  
 
     
     
       4. The method recited in  claim 3 , wherein the mixing step further comprises the step of adding to the mixture a derivative of at least one of the compounds 3-methylanthralin, chrysophanol, aloe-emodin, and aloe-emodin monoacetate. 
     
     
       5. A method for making an antipsoriatic composition comprising the step of mixing together 3-methylanthralin, chrysophanol, aloe-emodin, and aloe-emodin monoacetate. 
     
     
       6. The method recited in  claim 5 , further comprising the step of adding to the mixture a derivative of at least one of the compounds 3-methylanthralin, chrysophanol, aloe-emodin, and aloe-emodin monoacetate. 
     
     
       7. A composition comprising an extract from Asphodelus microcarpus and a pharmaceutical carrier for topical administration.  
     
     
       8. The composition of  claim 7 , wherein said pharmaceutical carrier is selected from the group consisting of gels, sprays, creams, and dermal patches.  
     
     
       9. The composition of  claim 7 , wherein said pharmaceutical carrier is a cream.  
     
     
       10. The composition of  claim 7 , wherein said pharmaceutical carrier is a gel.  
     
     
       11. The composition of  claim 7 , wherein said extract is included in said pharmaceutical carrier in an amount effective to reduce the symptoms of psoriasis.  
     
     
       12. The composition of  claim 7 , wherein said extract comprises effective amounts of  3 - methylanthralin, chrysophanol, aloe - emodin, and aloe - emodin acetate.    
     
     
       13. A method for treating psoriasis comprising
   a )  providing:      i )  a composition comprising an extract from Asphodelus microcarpus and a pharmaceutical carrier for topical administration; and        ii )  a patient having symptoms psoriasis; and          b )  topically applying said composition to said patient under conditions such that said symptoms of psoriasis are reduced.      
     
     
       14. The method of  claim 13 , wherein said pharmaceutical carrier is selected from the group consisting of liquids, gels, sprays, creams, and dermal patches.  
     
     
       15. The method of  claim 13 , wherein said pharmaceutical carrier is a cream.  
     
     
       16. The method of  claim 13 , wherein said pharmaceutical carrier is a gel.  
     
     
       17. The method of  claim 13 , wherein said extract is included in said pharmaceutical carrier in an amount effective to reduce the symptoms of psoriasis.  
     
     
       18. The method of  claim 13 , wherein said extract comprises effective amounts of  3 - methylanthralin, chrysophanol, aloe - emodin, and aloe - emodin acetate.    
     
     
       19. A method for preparing a pharmaceutical preparation comprising:
   a )  providing:      i )  an extract from Asphodelus microcarpus; and        ii )  a pharmaceutical carrier for topical administration; and          b )  preparing a pharmaceutical preparation from said extract and said pharmaceutical carrier.      
     
     
       20. The method of  claim 19 , wherein said pharmaceutical carrier is selected from the group consisting of liquids, gels, sprays, creams, and dermal patches.  
     
     
       21. The method of  claim 19 , wherein said pharmaceutical carrier is a cream.  
     
     
       22. The method of  claim 19 , wherein said pharmaceutical carrier is a gel.  
     
     
       23. The method of  claim 19 , wherein said extract is included in said pharmaceutical carrier in an amount effective to reduce the symptoms of psoriasis.  
     
     
       24. The method of  claim 19 , wherein said extract comprises effective amounts of  3 - methylanthralin, chrysophanol, aloe - emodin, and aloe - emodin acetate.    
     
     
       25. A pharmaceutical preparation prepared according to  claim 19 .  
     
     
       26. A composition comprising an effective amount of purified aloe- emodin monoacetate in a pharmaceutical carrier.    
     
     
       27. The composition of  claim 26 , wherein said effective amount is an amount sufficient to relieve the symptoms of psoriasis in a patient.  
     
     
       28. The composition of  claim 26 , further comprising at least one compound selected from the group consisting of  3 - methylanthralin, chrysophanol, and aloe - emodin.    
     
     
       29. The composition of  claim 26 , wherein said composition further comprises  3 - methylanthralin and chrysophanol.    
     
     
       30. The composition of  claim 26 , wherein said pharmaceutical carrier is selected from the group consisting of pills, tablets, capsules, liquids, gels, sprays, creams, dermal patches, and suppositories.  
     
     
       31. The composition of  claim 26 , wherein said pharmaceutical carrier is a cream.  
     
     
       32. The composition of  claim 26 , wherein said pharmaceutical carrier is a gel.  
     
     
       33. A composition comprising a cream including an effective amount of aloe- emodin monoacetate.    
     
     
       34. A composition comprising a gel including an effective amount of aloe- emodin monoacetate.    
     
     
       35. A method for preparing a pharmaceutical preparation comprising:
   a )  providing purified aloe - emodin monoacetate; and        b )  formulating said pharmaceutical preparation, wherein said pharmaceutical preparation comprises an effective amount of said substantially purified aloe - emodin monoacetate.      
     
     
       36. The method of  claim 35 , wherein said effective amount is an amount sufficient to relieve the symptoms of psoriasis in a patient.  
     
     
       37. The method of  claim 35 , further comprising providing at least one compound selected from the group consisting of  3 - methylanthralin, chrysophanol, and aloe - emodin and combining said at least one compound with said aloe - emodin monoacetate to provide said preparation.    
     
     
       38. The method of  claim 35 , wherein said pharmaceutical carrier is selected from the group consisting of pills, tablets, capsules, liquids, gels, sprays, creams, dermal patches, and suppositories.  
     
     
       39. The method of  claim 35 , wherein said pharmaceutical carrier is a cream.  
     
     
       40. The method of  claim 35 , wherein said pharmaceutical carrier is a gel.  
     
     
       41. A method for preparing a pharmaceutical preparation comprising:
   a )  providing purified aloe - emodin monoacetate and at least one compound selected from the group consisting of  3   - methylanthralin, chrysophanol, and aloe - emodin; and        b )  formulating said pharmaceutical preparation, wherein said pharmaceutical preparation comprises an effective amount of said purified aloe - emodin monoacetate and said at least one compound selected from the group consisting of  3   - methylanthralin, chrysophanol, and aloe - emodin.      
     
     
       42. The method of  claim 41 , wherein said effective amount is an amount sufficient to relieve the symptoms of psoriasis in a patient.  
     
     
       43. The method of  claim 41 , wherein said pharmaceutical preparation is selected from the group consisting of pills, tablets, capsules, liquids, gels, sprays, creams, dermal patches, and suppositories.  
     
     
       44. A method for preparing a pharmaceutical gel or cream comprising:
   a )  providing purified aloe - emodin monoacetae; and        b )  preparing a pharmaceutical gel or cream comprising an effective amount of said aloe - emodin monoacetate.      
     
     
       45. The method of  claim 44 , further comprising providing at least one compound selected from the group consisting of  3 - methylanthralin, chrysophanol, and aloe - emodin and combining said at least one compound with said aloe - emodin monoacetate to provide said preparation.    
     
     
       46. A method for inhibiting keratinocyte proliferation comprising
   a )  providing      i )  keratinocytes and        ii )  a composition comprising an effective amount of aloe - emodin monoacetate; and          b )  applying said composition to said keratinocytes, wherein said effective amount is sufficient to inhibit keratinocyte proliferation as compared to control samples.      
     
     
       47. The method of  claim 46 , wherein composition further comprises at least one compound selected from the group consisting of  3 - methylanthralin, chrysophanol, and aloe - emodin.    
     
     
       48. The method of  claim 46 , wherein said composition is a cream.  
     
     
       49. The method of  claim 46 , wherein said composition is a gel.  
     
     
       50. The method of  claim 46 , wherein said keratinocytes are from a patient suffering from psoriasis.  
     
     
       51. The method of  claim 46 , wherein said keratinocytes are from a patient suffering from eczema.