Stabilized aspirin compositions and method of preparation of oral and topical use

Abstract

Aspirin compositions for oral and topical use are stabilized by reaction with potassium hydroxide.

I claim:  
     
       1. A method for stabilizing salicylic acid (SA) and acetylsalicylic acid (ASA) for oral and topical use for mammals, the method comprising the steps of: 
       A. Combining the SA or ASA with potassium hydroxide (KOH) in a water based solution to form potassium salicylic acid (KSA) or potassium acetylsalicylic acid (KASA);  
       B. Dehydrating the KSA or KASA to form a stabilized dry KSA or KASA; and  
       C. Mixing the KSA or KASA with a liquid carrier for oral or topical use.  
     
     
       2. The method of  claim 1 , including the additional step of adding the SA or ASA and KOH to a point of supersaturation in the water based solution. 
     
     
       3. The method of  claim 2  wherein the KSA or KASA is mixed with water to form a dosing solution with a pH in the range of 8 to 10. 
     
     
       4. The method of  claim 2  wherein the KSA or KASA is mixed with a water based carrier including a dermitologically acceptable lotion, cream, gel or ointment with a resulting pH which is compatible to mammalian skin. 
     
     
       5. The method of  claim 2  wherein the step of dehydrating is performed by applying heat before the supersaturated solution cools from a temperature resulting from the combining step. 
     
     
       6. The method of  claim 1  wherein approximately one part by weight KOH is combined in the solution with two parts by weight ASA or  SA. 
     
     
       7. The method of  claim 1  wherein approximately  1 . 0  part by weight KOH is combined in the solution with approximately  1 . 3  parts by weight ASA.