Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives

Abstract

The present invention relates to anti-neoplastic and anti-psoriasis pharmaceutical compositions and methods of treatment and to insecticidal compositions and methods of controlling the growth of insects.

I claim:  
     
       1. A compound having the formula:                    
       Wherein: 
       R 1 -R 6  may be the same or different and are methyl, propyl, butyl, pentyl, benzyl or β,β,β,-trifluoro-ethyl;  
       m is an integer from  3 to ,  4 ,  5 , or 6, inclusive ; and  
       n is an integer from  3 to ,  4 ,  5 , or 6, inclusive, ;  
       or a salt thereof with an acid;  
         with the proviso that if m is  3 , and n is  3  or  4 , then at least one of R   1   -R   6    is β,β,β, - trifluoroethyl.    
     
     
       2. A compound according to  claim 1  wherein R 1  and R 6  are propyl. 
     
     
       3. A compound according to  claim 1  wherein R 1  and R 6  are benzyl. 
     
     
       4. A compound according to  claim 1  wherein m is 3 and n is 4. 
     
     
       5. A compound according to  claim 1  wherein m and n are 3. 
     
     
       6. A compound according to  claim 1  wherein m and n are 4. 
     
     
       7. A compound having the formula: 
       
         
           R 1 —N 1 H—(CH 2 ) 3 —N 2 H—(CH 2 ) 3 —N 3 H—(CH 2 ) 4 —N 4 H—(CH 2 ) 3 —N 5 H—(CH 2 ) 3 —N 6 H—R 6   (II)  
         
       
       Wherein: 
       R 1  and R 6  may be the same or different and are alkyl or aralkyl having from 1 to 12 carbon atoms, or a salt thereof with an acid.  
     
     
       8. A compound according to  claim 7  wherein R 1  and R 6  are alkyl. 
     
     
       9. A compound according to  claim 7  wherein R 1  and R 6  are aralkyl. 
     
     
       10. A compound according to  claim 7  wherein R 1  and R 6  are methyl. 
     
     
       11. A compound according to  claim 7  wherein R 1  and R 6  are ethyl. 
     
     
       12. A compound according to  claim 7  wherein R 1  and R 6  are propyl. 
     
     
       13. A compound according to  claim 7  wherein R 1  and R 6  are benzyl. 
     
     
       14. A compound having the formula: 
       
         
           CH 3 CH 2 —NH—(CH 2 ) 4 —NH—(CH 2 ) 4 —NH—(CH 2 ) 4 —NH—CH 2 CH 3 .