Transdermal therapeutic system

Abstract

A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots ( 14 ) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix ( 12 ).

What is claimed is:  
     
       1. A sealing bag containing a nicotine patch comprising: 
       a) a butadiene-acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, and  
       b) a composite layer comprising paper and, aluminum,  
       c) wherein the layers form a bag which is sealed on four edges, and  
       d) wherein a nicotine patch is contained within said bag.  
     
     
       2. A sealing bag according to  claim 1 , wherein the copolymer layer comprises a copolymer formed from about 73-77 parts by weight of acrylonitrile copolymerized with 23-27 parts by weight of methyl acrylate in the presence of 8-10 parts by weight of butadiene acrylonitrile copolymer containing about 70% by weight of polymer units derived from butadiene. 
     
     
       3. The sealing bag of  claim 1  further comprising a protective layer forming the external surface of said sealing bag. 
     
     
       4. The sealing bag of  claim 2  further comprising a protective layer forming the external surface of said sealing bag. 
     
     
       5. The sealing bag of  claim 1  wherein said composite is disposed on the external surface of said copolymer layer. 
     
     
       6. The sealing bag of  claim 2 , wherein said composite is disposed on the external surface of said copolymer layer. 
     
     
       7. A sealing bag containing a nicotine patch comprising a four edged sealing bag made of a composite comprising paper, aluminum and a butadiene-acrylonitrile modified acrylonitrile methyl acrylate copolymer, and wherein the nicotine patch is contained within said bag. 
     
     
       8. A sealing bag consisting of: 
       a) a thermoplastic butadiene-acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, and  
       b) a composite layer consisting of paper and aluminum,  
       c) wherein the layers from a bag which is sealed on four edges, and  
       d) wherein a nicotine patch is contained within said bag.  
     
     
       9. A sealing bag containing a nicotine patch comprising a four edged sealing bag made of a composite consisting of paper, aluminum and a thermoplastic butadiene-acrylonitrile modified acrylonitrile methyl acrylate copolymer, and wherein the nicotine patch is contained within said bag. 
     
     
       10. A sealing bag according to  claim 8 , wherein the copolymer layer comprises a copolymer formed from about 73-77 parts by weight of acrylonitrile copolymerized with 23-27 parts by weight of methyl acrylate in the presence of 8-10 parts by weight of butadiene acrylonitrile copolymer containing about 70% by weight of polymer units derived from butadiene. 
     
     
       11. The sealing bag of  claim 8 , wherein said composite is disposed on the external surface of said copolymer layer. 
     
     
       12. The sealing bag of  claim 10 , wherein said composite is disposed on the external surface of said copolymer layer. 
     
     
       13. The sealing bag of  claim 8  further comprising a protective layer forming the external surface of said sealing bag. 
     
     
       14. The sealing bag of  claim 10  further comprising a protective layer forming the external surface of said sealing bag. 
     
     
       15. A sealing bag according to  claim 7 , wherein the copolymer layer comprises a copolymer formed from about 73-77 parts of acrylonitrile copolymerized with 23-27 parts by weight of methyl acrylate in the presence of 8-10 parts by weight of butadiene acrylonitrile copolymer containing about 70% by weight of polymer units derived from butadiene. 
     
     
       16. The sealing bag of  claim 7 , wherein said composite is disposed on the external surface of said copolymer. 
     
     
       17. The sealing bag of  claim 15 , wherein said composite is disposed on the external surface of said copolymer layer. 
     
     
       18. The sealing bag of  claim 7  further comprising a protective layer forming the external surface of said sealing bag. 
     
     
       19. The sealing bag of  claim 15  further comprising a protective layer forming the external surface of said sealing bag. 
     
     
       20. A sealing bag according to  claim 9 , wherein the copolymer layer comprises a copolymer formed from about 73-77 parts by weight of acrylonitrile copolymerized with 23-27 parts by weight of methyl acrylate in the presence of 8-10 parts by weight of butadiene acrylonitrile copolymer containing about 70% by weight of polymer units derived from butadiene. 
     
     
       21. The sealing bag of  claim 9 , wherein said composite is disposed on the external surface of said copolymer layer. 
     
     
       22. The sealing bag of  claim 20 , wherein said composite is disposed on the external surface of said copolymer layer. 
     
     
       23. The sealing bag of  claim 9  further comprising a protective layer forming the external surface of said sealing bag. 
     
     
       24. The sealing bag of  claim 20  further comprising a protective layer forming the external surface of said sealing bag. 
     
     
       25. A sealing bag containing a nicotine patch comprising a combination of 
         a )  a butadiene - acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, and    
         b )  a layer comprising aluminum,    
       
         wherein the layers form a bag which is sealed on all edges and the nicotine patch is contained within said bag. 
       
     
     
       26. A sealing bag containing a nicotine patch comprising a bag sealed on all edges made of a composite comprising an aluminum layer and a butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, wherein the nicotine patch is contained within said bag.   
     
     
       27. A sealing bag consisting of a combination of 
         a )  a thermoplastic butadiene - acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, and    
         b )  an aluminum layer,    
       
         wherein said layers form a bag which is sealed on all edges and a nicotine patch is contained within said bag. 
       
     
     
       28. A sealing bag containing a nicotine patch comprising a bag sealed on all edges comprising a composite consisting essentially of an aluminum layer and a thermoplastic butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, wherein the nicotine patch is contained within said bag.   
     
     
       29. A sealing bag as claimed in  claim 25 , which is sealed on four edges. 
     
     
       30. A sealing bag as claimed in  claim 26 , which is a four edged sealing bag. 
     
     
       31. A sealing bag as claimed in  claim 27 , which is sealed of four edges. 
     
     
       32. A sealing bag as claimed in  claim 28 , which is a four edged sealing bag. 
     
     
       33. A sealing bag as claimed in  claim 25 , which further comprises a paper layer. 
     
     
       34. A sealing bag as claimed in  claim 26 , wherein the composite further comprises a paper layer. 
     
     
       35. A sealing bag as claimed in  claim 27 , wherein layer ( b )  further comprises a paper layer.   
     
     
       36. A sealing bag containing a nicotine patch comprising a bag sealed on all edges comprising a composite consisting essentially of a paper layer, an aluminum layer and a thermoplastic butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, wherein the nicotine patch is contained within said bag.   
     
     
       37. A bag for a patch with an active substance comprising a sealing bag made of a composite comprising an aluminum layer and a butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer wherein the patch with the active substance is contained within said bag.   
     
     
       38. The bag according to  claim 37 , where the active substance is nicotine. 
     
     
       39. The bag according to  claim 37 , wherein the sealing bag is sealed on four edges. 
     
     
       40. The bag according to  claim 37 , wherein the composite further comprises a paper layer. 
     
     
       41. A bag for a patch with an active substance comprising a sealing bag made of a composite comprising a degradation agent barrier layer for said active substance and a butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer wherein said layers are in contact with each other and the active substance is contained in the patch within said bag.   
     
     
       42. The bag according to  claim 41 , wherein the sealing bag is sealed on four edges. 
     
     
       43. The bag according to  claim 41 , wherein the composite further comprises a protective layer. 
     
     
       44. The bag according to  claim 43 , wherein the protective layer is paper and the active substance is nicotine. 
     
     
       45. A sealing bag containing a nicotine patch comprising a bag sealed on all edges made of a composite comprising an aluminum layer and a butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, wherein said layers are in contact with each other and the nicotine patch is contained within said bag.   
     
     
       46. A sealing bag consisting of a combination of 
         a )  a thermoplastic butadiene - acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, and    
         b )  an aluminum layer,    
       
         wherein the layers are in contact with each other and form a bag which is sealed on all edges and a nicotine patch is contained within said bag. 
       
     
     
       47. A sealing bag containing a nicotine patch comprising a bag sealed on all edges comprising a composite consisting essentially of an aluminum layer and a thermoplastic butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, wherein said layers are in contact with each other and the nicotine patch is contained within said bag.   
     
     
       48. A sealing bag as claimed in  claim 45 , which is a four edged sealing bag. 
     
     
       49. A sealing bag as claimed in  claim 46 , which is sealed on four edges. 
     
     
       50. A sealing bag as claimed in  claim 47 , which is a four edged sealing bag. 
     
     
       51. A sealing bag as claimed in  claim 45 , wherein the composite further comprises a paper layer. 
     
     
       52. A sealing bag as claimed in  claim 46 , wherein layer ( b )  further comprises a paper layer.   
     
     
       53. A sealing bag containing a nicotine patch comprising a bag sealed on all edges comprising a composite consisting essentially of a paper layer, an aluminum layer and a thermoplastic butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer, wherein said layers are in contact with each other and the nicotine patch is contained within said bag.   
     
     
       54. A bag for a nicotine patch comprising a sealing bag made of a composite comprising an aluminum layer and a butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer wherein said layers are in contact with each other and the nicotine patch is contained within said bag.   
     
     
       55. The bag according to  claim 54 , wherein the sealing bag is sealed on four edges. 
     
     
       56. The bag according to  claim 54 , wherein the composite further comprises a paper layer. 
     
     
       57. A bag for a nicotine patch comprising a sealing bag made of a composite comprising a degradation agent barrier layer for said nicotine patch and a butadiene- acrylonitrile modified acrylonitrile methyl acrylate copolymer layer wherein said layers are in contact with each other and a nicotine patch is contained within said bag.   
     
     
       58. The bag according to  claim 57 , wherein the sealing bag is sealed on four edges. 
     
     
       59. The bag according to  claim 57 , wherein the composite further comprises a protective layer. 
     
     
       60. The bag according to  claim 57 , wherein the protective layer is paper. 
     
     
       61. A sealing bag for an active substance that can be applied in a transdermal manner comprising an acrylonitrile methyl acrylate copolymer containing medicament barrier layer and an aluminum- containing medicament - degradation agent barrier.   
     
     
       62. The sealing bag of  claim 61 , further including a paper protective layer. 
     
     
       63. The sealing bag of  claim 61 , wherein the transdermal substance is nicotine. 
     
     
       64. The sealing bag of  claim 62 , wherein the transdermal substance is nicotine. 
     
     
       65. The sealing bag of  claim 61 , wherein the active substance that can be applied in a transdermal manner is sealed within same sealing bag. 
     
     
       66. The sealing bag of  claim 62 , wherein the active substance that can be applied in a transdermal manner is sealed within same sealing bag. 
     
     
       67. The sealing bag of  claim 65 , wherein the active substance is nicotine that can be applied in a transdermal manner and is sealed within same sealing bag. 
     
     
       68. The sealing bag of  claim 66 , wherein the active substance is nicotine that can be applied in a transdermal manner and is sealed within same sealing bag.