Method and composition for inhibiting bacteria

Abstract

A composition comprising a trivalent bismuth salt, particularly bismuth nitrate, and dimercaprol is described. Methods for using the composition as a bacteriocidal and bacteriostatic agent and as a disinfectant and preservative are also provided.

What is claimed is:  
     
       1. A composition, comprising: 
       a trivalent bismuth salt; and  
       at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol, wherein the molar ratio of said trivalent bismuth salt to said compound is approximately 1:2 to approximately  3:1.  1:1 to approximately 3:1.   
     
     
       2. A composition, as recited in  claim 1 , wherein said trivalent bismuth salt is selected from the group consisting of bismuth nitrate, colloidal bismuth subcitrate and bismuth subsalicylate. 
     
     
       3. A composition, as recited in  claim 1 , wherein said molar ratio is approximately 1:1 to approximately 3:1. 
     
     
       4. A composition, as recited in  claim 1 , wherein said molar ratio is approximately 2:1 to approximately 3:1. 
     
     
       5. A composition, as recited in  claim 1 , further comprising a pharmaceutically acceptable diluent or carrier. 
     
     
       6. A composition, comprising: 
       a trivalent bismuth salt; and  
       at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol, wherein said trivalent bismuth salt and said compound are present in the molar ratio of approximately 3:1.  
     
     
       7. A method of preventing or inhibiting bacterial infection, comprising the step of: 
       administering a therapeutically effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol to a patient, in need thereof.  
     
     
       8. A method, as recited in  claim 7 , wherein said trivalent bismuth salt is selected from the group consisting of bismuth nitrate, colloidal bismuth subcitrate and bismuth subsalicylate. 
     
     
       9. A method, as recited in  claim 8 , wherein the molar ratio of said trivalent bismuth salt to said compound is not less than approximately 1:2 nor more than approximately 3:1. 
     
     
       10. A method, as recited in  claim 9 , wherein said molar ratio is approximately 1:1 to approximately 3:1. 
     
     
       11. A method, as recited in  claim 9 , wherein said molar ratio is approximately 2:1 to approximately 3:1. 
     
     
       12. A method of eradicating bacteria, comprising the step of: 
       applying to an area on which it is desired to eradicate bacteria on effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol.  
     
     
       13. A method, as recited in  claim 12 , wherein said trivalent bismuth salt is selected from the group consisting of bismuth nitrate, colloidal bismuth subcitrate and bismuth subsalicylate. 
     
     
       14. A method, as recited in  claim 13 , wherein the molar ratio of said trivalent bismuth salt to said compound is not less than approximately 1:2 nor more than approximately 3:1. 
     
     
       15. A method, as recited in  claim 14 , wherein said molar ratio is approximately 1:1 to approximately 3:1. 
     
     
       16. A method, as recited in  claim 14 , wherein said molar ratio is approximately 2:1 to approximately 3:1. 
     
     
       17. A method of preventing the formation of growth of biofilms, comprising the step of: 
       applying to an area on which it is desired to prevent the formation or growth of biofilms an effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol.  
     
     
       18. A method of preventing spoilage, comprising the step of: 
       applying to a product on which it is desired to prevent spoilage an effective amount of a composition comprising a trivalent bismuth salt and at least one compound selected from the group consisting of dimercaprol, β-mercaptoethanol and dithiothreitol.