Adenosine derivatives and pharmaceutical composition thereof

Abstract

The present invention relates to novel adenosine derivatives having the formula (I):wherein R is a lower alkyl group; R' is hydrogen or a lower alkyl group; X is a cycloalkyl group, an alkyl group having at least one hydroxy group, an alkyl group having at least one phenyl group, a bicycloalkyl group, a naphthylalkyl group, an acenaphthylenylalkyl group or a group of the formula (II) or (III);Z is hydrogen, a hydroxy group or a lower alkoxy group, Q is hydrogen or a hydroxy group, A is -CH2-, -O-, -S- or shows a direct connection; Y is -(CH2)n- or shows a direct connection; n is an integer of 1 to 3; and the broken line is a double bond or a single bond.and pharmaceutically acceptable salt thereof, which are useful as antihypertensive agents.

What is claimed is:  
     
       1. An adenosine compound of the formula (I):                    
       wherein R is a C 1-3  alkyl group; R′ is hydrogen or a C 1-3  alkyl group; X is a C 3-8  cycloalkyl group,  a C 1-4  alkyl group having one or two hydroxy groups, a C 1-3  group havine one or two phenyl groups,  a bicycloheptyl group, a C 1-3  alkyl group having a naphthyl group, a C 1-3  alkyl group having an acenaphthylenyl group, or a group of the formula (II) or (III);                    
       wherein Z is hydrogen, a hydroxy group or a C 1-3  alkoxy group, Q is hydrogen or a hydroxy group, A is —CH 2 —, —o—, —s— or shows a direct connection; Y is —(CH 2 ) n — or shows a direct connection; n is an integer of 1 to 3; and the broken line represents the presence or absence of a second bond, or a pharmaceutically acceptable salt thereof. 
     
     
       2. An adenosine compound or a salt thereof according to claim  1  wherein R′ is hydrogen. 
     
     
       3. A pharmaceutical composition comprising as an active ingredient an effective amount of an adenosine compound or salt thereof of claim  1 , together with a pharmaceutically acceptable carrier. 
     
     
       4. A method for treating hypertension in a mammal which comprises administering to the mammal an antihypertensive effective amount of at least one adenosine compound or pharmaceutically acceptable salt thereof of claim  1 .