Amino-oxazole compounds having dopaminergic activity

Abstract

The present invention relates to new amino-thiazole and amino-oxazole derivatives of the general formula: ##STR1## wherein: R represents hydrogen, a lower alkyl group with 1 to 4 carbon atoms, a lower alkenyl group, a phenyl-alkyl (1-4 C), furanyl-alkyl (1-4 C) or thienyl-alkyl (1-4 C) group; X represents sulphur or oxygen; R 1 and R 2 represent hydrogen or alkyl (1-4 C), and the dotted line represents an optional extra bond, as well as pharmaceutically acceptable acid addition salts thereof, having potent dopamine-agonist activity.

We claim: 
     
       1. Amino-oxazole derivatives of the formula: ##STR6## wherein: R represents hydrogen; .Iadd.a lower alkyl group with 2-4 carbon atoms, a lower alkenyl group, a phenyl alkyl (2-4C), furanyl alkyl (1-4C) or thienyl alkyl (2-4C) group; .Iaddend.   X represents oxygen;   R 1  and R 2  represent hydrogen or alkyl (1-4 C), and the dotted line represents an optional extra bond, as well as pharmaceutically acceptable acid addition salts thereof.   
     
     
       2. Compounds according to claim 1, in which the dotted line is an extra bond, and pharmaceutically acceptable salts thereof. 
     
     
       3. Compounds according to claim 1, in which R 1  and R 2  represent both hydrogen and pharmaceutically acceptable salts thereof. 
     
     
       4. Pharmaceutical composition comprising an effective amount of the compound of claim 1 to provide dopamineagonist activity when administered to a patient, together with one or more pharmaceutically acceptable carriers or diluents.