USRE33403EExpiredUtility

Method for treating disorders of the vascular and pulmonary systems

Priority: Jun 3, 1982Filed: Jan 13, 1989Granted: Oct 23, 1990
Est. expiryJun 3, 2002(expired)· nominal 20-yr term from priority
A61K 35/54A61K 35/20C07K 2317/11
30
PatentIndex Score
22
Cited by
6
References
15
Claims

Abstract

A method for treating vascular disorders or pulmonary disorders associated with smoking in an animal which comprises: adminstering to the animal milk collected from a bovid being maintained in a hyperimmune state, in an amount and for a time sufficient to produce anti arteriosclerotic or antiaging vascular effects or sparing effects on lung tissue.

Claims

exact text as granted — not AI-modified
What is new and claimed and intended to be covered by Letters Patent of the United States is: 
     
       1. A method of lowering lipid blood stream levels in an animal which comprises: administering to said animal milk collected from a bovid being maintained in a hyperimmune state against a mixture of antigens comprising Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pyogenes, A. Type 1; Streptococcus pyogenes, A. Type 3; Streptococcus pyogenes, A. Type 5; Streptococcus pyogenes, A. Type 8; Streptococcus pyogenes, A. Type 12; Streptococcus pyogenes, A. Type 14; Streptococcus pyogenes, A. Type 18; Streptococcus pyogenes, A. Type 22; Aerobacter aerogenes; Escherichia coli; Salmonella enteritidis; Pseudomonas aeruginosa; Klebsiella pneumoniae; Salmonella typhimurium; Haemophilus influenzae; Streptococcus viridans; Proteus vulgaris; Shigella dysenteriae; Streptococcus, Group B; Diplococcus pneumoniae; Streptococcus mutans; and Corynebacterium Acne, Types 1 and 2, in an amount and for a time sufficient to produce said lowering effect.   
     
     
       2. The method of claim 1 wherein said milk is in powdery form. 
     
     
       3. The method of claim 1 wherein said milk is in fluid form. 
     
     
       4. The method of claim 1 wherein said milk is in concentrated form. 
     
     
       5. The method of claim 1 wherein said milk is incorporated into a food product. 
     
     
       6. The method of claim 4 wherein said product is yogurt. 
     
     
       7. The method of claim 1 wherein said bovid is a cow. 
     
     
       8. The method of claim 1 wherein said bovid is maintained in said hyperimmune state by administering to said bovid booster injections of a mixture of antigens comprising Staphylococcus aureus; Staphylococcus epidermus; Streptococcus pyogenes, A. Type 1; Streptococcus pyogenes, A. Type 3; Streptococcus pyogenes, A. Type 5; Streptococcus pyogens, A. Type 8; Streptococcus pyogenes, A. Type 12; Streptococcus pyogenes, A. Type 14; Streptococcus pyogenes, A. Type 18; Streptococcus pyogenes, A. Type 22; Aerobacter aerogenes; Escherichia coli; Salmonella enteritidis; Pseudomonas aeruginosa; Klebsiella pneumoniae; Salmonella typhimurium; Haemophilus influenzae; Streptococcus viridans; Proteus vulgaris; Shigella dysenteriae; Streptococcus, Group B; Diplococcus pneumoniae; Streptococcus mutans; and Corynebacterium Acne, Types 1 and 2. 
     
     
       9. The method of claim 8 wherein said antigen or mixture of antigens booster is injected in a dose of 10 6  cells to 10 20  cells. 
     
     
       10. The method of claim 4 wherein said milk is prepared by a process which comprises: sensitizing a bovid with said mixture of antigens;   administering boosters of said mixture of antigens of a dosage sufficient to induce and maintain a hyperimmume state in said bovid, and thereafter collecting said milk from said bovid.   
     
     
       11. The method of claim 10 wherein said process further comprises: pasteurizing said collected milk; and   removing the fat from said milk.   
     
     
       12. The method of claim 1 wherein said milk is administered daily. 
     
     
       13. The method of claim 1, wherein said lipids are selected from the group consisting of triglycerides, cholesterol, low density lipids and mixtures thereof. .Iadd. 
     
     
       14.  A method of lowering lipid blood stream levels in an animal which comprises administering to said animal, in an amount and for a time sufficient to produce said lowering effect, milk collected from a bovid being maintained in a hyperimmune state against bacterial, viral or cellular antigens or a mixture of two or more of said antigens. .Iaddend. .Iadd. 
     
     
       15.  The method according to claim 14 wherein said bovid is maintained in a hyperimmune state against a bacterial antigen or antigens. .Iaddend. .Iadd.16. A method according to claim 15 wherein said bacterial antigens are selected from the group consisting of Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pyogenes, A. Type 1; Streptococcusi pyogenes, A. Type 3; Streptococcus pyogenes, A. Type 5; Streptococcus pyogenes, A. Type 8; Streptococcus pyogenes, A. Type 12; Streptococcus pyogenes, A. Type 14; Streptococcus pyogenes, A. Type 18; Streptococcus pyogenes, A. Type 22; Aerobacter aerogenes; Salmonella enteritidis; Klebsiella pneumoniae; Salmonella typhimurium; Haemophilus influenzae; Streptococcus viridans; Proteus vulgaris; Shigella dysenteriae; Streptococcus, Group B; Diplococcus pneumoniae; Corynebacteriumn, Acne, Types 1 and 2; Pseudomonas aeruginosa; Pseudomonas maltophiia; Streptococcus equisimili; Streptococcus dysgalactiae; Streptococcus uberis; Streptococcus bovis; Pasteurella multocida; Pasteurella haemolytica; Pasteurella multocida; Moraxella bovis; Actinobacillus lignieresi; Corynebacterium renale; Fusobacterium necrophorum; Bacillus cereus; Salmonella dublin; Salmonella heidleberg; Salmonella paratyphi; Yersinia enterocolitica; Streptococcus mutans; and Escherichia coli. .Iaddend. .Iadd.17. The method of claim 15 wherein said bacterial antigens are selected from the group consisting of Pseudomonas aeruginosa; Pseudomonas maltophiia; Streptococcus equisimili; Streptococcus dysgalactiae; Streptococcus uberis; Streptococcus bovis; Streptococcus bovis; Pasteurella multocida; Pasteurella multocida; Pasteurella haemolytica; Pasteurella multocida; Moraxella bovis; Actinobacillus lignieresi; Corynebacterium renale; Fusobacterium necrophorum; Bacillus cereus; Salmonella dublin; Salmonella heidleberg; Salmonella paratyphi; and Yersinia enterocolitica. .Iaddend. .Iadd.18. The method of claim 15 wherein said bacterial antigen comprises Streptococcus mutans. .Iaddend. .Iadd.19. The method of claim 18 wherein said antigen is selected from the group consisting of Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans 10499, and Streptococcus mutans 6715. .Iaddend. .Iadd.20. The method of claim 18 wherein said antigen comprises Streptococcus mutans AHT, Streptococcus mutans BHT, Streptococcus mutans 10499, and Streptococcus mutans 6715. .Iaddend. 
     
     
        .Iadd.1.  The method of claim 15 wherein said bacterial antigen comprises Escherichia coli. .Iaddend. .Iadd.22. The method of claim 14 or 15 wherein said milk is in a powdery form, a fluid form, a concentrated form, incorporated into a food product, or in yogurt. .Iaddend. .Iadd.23. The method of claim 14 or 15 wherein said bovid is maintained in said hyperimmune state by administering to said bovid booster injections of an antigen or antigens. .Iaddend. .Iadd.24. The method claim 14 or 15 wherein said milk is prepared by a process which comprises sensitizing a bovid with an antigen or antigens;   administering boosters of said antigen or antigens of a dosage sufficient to induce and maintain a hyperimmune state in said bovid and thereafter collecting said milk from said bovid. .Iaddend. .Iadd.25. The method of claim 24 wherein said process further comprises:   pasteurizing said collected milk; and   removing the fat from said milk. .Iaddend. .Iadd.26. The method of claim 14 wherein said milk is administered daily. .Iaddend.

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