Bronchodilating 8-hydroxy-5-(1R)-1-hydroxy-2-(N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)-amino)ethyl) carbostyril and intermediates thereof

Abstract

A novel carbostyril derivative of the formula:or a pharmaceutically acceptable acid addition salt thereof, and a process for preparing same. The conpound (I) shows potent bronchodilating activity and is useful as a bronchodilator.

What we claim is: 
     
       1. A carbostyril compound of the formula: ##STR15## or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       2. The compound of claim 1 which is a mixture of 8-hydroxy-5-{(1R)-1-hydroxy-2-[N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)amino]ethyl}carbostyril and 8-hydroxy-5-{(1S)-1-hydroxy-2-[N-((1S)-2-(p-methoxyphenyl)-1-methylethyl)amino]ethyl}carbostyril, or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       3. The compound of claim 1 which is 8-hydroxy-5-{(1R)-1-hydroxy-2-[N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)amino]ethyl}carbostyril or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       4. A pharmaceutical composition which comprises a therapeutically effective amount of a bronchodilating compound of the formula: ##STR16## or a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutically acceptable carrier therefor. 
     
     
       5. A method of producing a bronchodilating effect on a warm-blooded animal comprising administering to said warm-blooded animal an effective amount of a compound of the formula: ##STR17## or a pharmaceutically acid addition salt thereof. .Iadd. 
     
     
       6.  A carbostyril compound of the formula ##STR18## wherein Y is benzyl, p-methoxybenzyl, or 3-4-dimethoxybenzyl. .Iaddend. .Iadd. 
     
     
       7.  The compound according to claim 6 wherein Y is benzyl. .Iaddend.