Method of enhancing the effect of t-PA

Abstract

The absorption rate of protein-thrombolytic agents with medicinal properties in the blood is enhanced by administering the protein intramuscularly together with an absorption enhancing agent, e.g. hydroxylamine or a salt thereof.

What is claimed is: 
     
       1. A method of increasing the .[.absorption.]. .Iadd.effect .Iaddend.of t-PA in the blood in a mammal in need of t-Pa therapy comprising administering to the mammal .Iadd.exogenous t-PA and .Iaddend.an amount of t-PA inhibitor disassociating agent effective to increase the disassociation of the inhibitor from the t-PA, the amount of exogenous t-PA being less than that required to be administered in the absence of the inhibitor disassociating agent. 
     
     
       2. A method according to claim 1 wherein the inhibitor dissociating agent is added intramuscularly. 
     
     
       3. A method according to claim 1 wherein the inhibitor disassociating agent is added intravenously. 
     
     
       4. A method according to claim 1 wherein the inhibitor disassociating agent is hydroxylamine or a non-toxic salt thereof. 
     
     
       5. A method according to claim 4 wherein the inhibitor dissociating agent is added intramuscularly. 
     
     
       6. A method according to claim 4 wherein the inhibitor disassociating agent is added intravenously. 
     
     
       7. A method according to claim 4 wherein the inhibitor disassociating agent is hydroxylamine hydrochloride.