Antihyperlipidemic compositions

Abstract

The invention concerns cyclic imides, diones, reduced diones and analogs thereof which are useful as antihyperlipidemic agents to reduce serum cholesterol and trigylcerides.

What is claimed is: 
     
       1. Antihyperlipidemic compositions comprising a pharmaceutically acceptable carrier and, as the principal active ingredient, .Iadd.N-phthalimido-o-acetophenone or .Iaddend.a compound of the group represented by the .[.formulas.]. .Iadd.formulae.Iaddend.: ##STR2## wherein X is aryl, cycloalkyl, or cycloalkylene containing up to ten carbon atoms; Y is CH or N; Z is alkyl containing up to five carbon atoms, carboxyl, carboalkoxyl wherein the alkyl group contains up to four carbon atoms, acyl containing up to four carbon atoms, alkylene, aryl, aralkyl or .[.aralhylene.]. .Iadd.aralkylene.Iaddend.; n is 1 to 10; and further compounds wherein the group represented by X is replaced with at least one hydrogen on each of the carbon atoms adjacent the oxygen bearing functional groups and .Iadd.wherein X is unsubstituted or mono-substituted with halogen or alkyl group containing up to 5 carbon atoms and .Iaddend.pharmaceutically acceptable acid.[.;.]. and alkali metal addition salts thereof. 
     
     
       2. A composition as in claim 1 wherein the compound is 3-N-(1,8-naphthalamido)propionic acid. 
     
     
       3. A composition as in claim 1 wherein the compound is 3-N-succinimido propionic acid. 
     
     
       4. A composition as in claim 1 wherein the compound is 3-N-saccharin propionic acid. 
     
     
       5. A composition as in claim 1 wherein the compound is N-phthalimido o-acetophenone. 
     
     
       6. A composition of claim 1 wherein the compound is 3-N-phthalimidopropionic acid. 
     
     
       7. A compound as in claim 1 wherein n is 2 to 4. 
     
     
       8. A method of controlling hyperlipidemia in mammals which comprises administering to said mammal an effective amount for controlling hyperlipidemia of .Iadd.N-phthalimido-o-acetophenone or .Iaddend.a compound of the formula: ##STR3## wherein X is aryl, cycloalkyl, or cycloalkylene containing up to ten carbon atoms; Y is CH or N; Z is alkyl containing up to five carbon atoms, carboxyl, carboalkoxy wherein the alkyl group contains up to four carbon atoms, acyl containing up to four carbon atoms, alkylene, aryl, aralkyl or aralkylene; n is 1 to 10; and further compounds wherein the group represented by X is replaced with at least one hydrogen on each of the carbon atoms adjacent the oxygen bearing functional groups and pharmaceutically acceptable acid; and alkali metal addition salts thereof. 
     
     
       9. A method as in claim 8 wherein the compound is 3-N-(1,8-naphthalamido)propionic acid. 
     
     
       10. A method as in claim 8 wherein the compound is 3-N-succinimido propionic acid. 
     
     
       11. A method as in claim 8 wherein the compound is 3-N-saccharin propionic acid. 
     
     
       12. A method as in claim 8 wherein the compound is N-phthalimido o-acetophenone. 
     
     
       13. A method as in claim 8 wherein the compound is 3-N-phthalimidopropionic acid. 
     
     
       14. A method as in claim 8 wherein the compound is one in which n is 2 to 4.