Method of treating inflammation

Abstract

A method of treating inflammation and inhibiting prostaglandin synthesis employing substituted 2-(arylmethoxy)phenol compounds.

What I claim is: 
     
       1. A method of treating inflammation in mammals, which method comprises administering to the mammal a therapeutical effective amount of a compound of the formula: ##STR3## where X is selected from the group consisting of: (a) naphthyl, pyridyl, quinolyl and 2-benzimidazolyl; and (b) .Iadd.phenyl radical or .Iaddend.a .Iadd.mono or di .Iaddend.substituted phenyl having .[.the structural formula ##STR4## where R, R' and R" are hydrogen,.]. .Iadd.radical substituent groups selected from the group consisting of .Iaddend.halogen, C 1  -C 6  alkyl, C 1  -C 6  haloalkyl, C 1  -C 6  alkoxy or combinations thereof and the nontoxic pharmaceutically acceptable salts thereof. .[.   
     
     
       2.  The method of claim 1 wherein R' and R" are halogen radicals and R is hydrogen..]. .[.3. The method of claim 1 wherein R is a hydrogen, R' is a methyl radical and R" is a chloro radical..]. .[.4. The method of claim 1 wherein R is hydrogen, R' is a trihalomethyl radical and R" is a methyl radical..]. .[.5. The method of claim 1 wherein R is hydrogen and R' and R" are methyl radicals..]. .[.6. The method of claim 1 wherein R and R' are chloro radicals and R" is a methyl radical..]. .[.7. The method of 
     
     
        claim 1 wherein R and R' are methyl radicals and R" is hydrogen..]. .[.8. The method of claim 1 wherein R and R' are methoxy radicals and R" is 
     
     
        hydrogen..]. 9. The method of claim 1 wherein the compound is selected from the group consisting of: 2-(2-methylphenylmethoxy)phenol; 2-(3-chlorophenylmethoxy)phenol; 2-(3-trifluoromethylphenylmethoxy)phenol; 2-(4-methoxyphenylmethoxy)phenol; 2-(2,5-dimethylphenylmethoxy)phenol; 2-(2-naphthalenylmethoxy)phenol; 2-(2-pyridylmethoxy)phenol; 
     
     
        2-(2-benzimidazolylmethoxy)phenol; and 2-(2-quinolylmethoxy)phenol. 10. The method of claim 1 which comprises applying topically to the inflammed area a pharmaceutical composition containing a pharmaceutically acceptable carrier material and from about 0.001 to 5% by weight of the 
     
     
        compound. 11. A pharmaceutical composition for the treatment of inflammation, which composition comprises a pharmaceutically accepted carrier material and from about 0.001% to 5% by weight of a 2-(arylmethoxy)phenol compound selected from the group consisting of: (a) 2-(2-methylphenylmethoxy)phenol;   (b) 2-(3-chlorophenylmethoxy)phenol;   (c) 2-(3-trifluoromethylphenylmethoxy)phenol;   (d) 2-(4-methoxyphenylmethoxy)phenol;   (e) 2-(2,5-dimethylphenylmethoxy)phenol;   (f) 2-(2-naphthalenylmethoxy)phenol;   (g) 2-(2-pyridylmethoxy)phenol;   (h) 2-(2-benzimidazolylmethoxy)phenol; and   (i) 2-(2-quinolylmethoxy)phenol and their pharmaceutically accepted salts. .Iadd. 12. The method of claim 1 wherein the substituent group is a methyl group. .Iaddend..Iadd. 13. The method of claim 1 wherein the substituent group is a halogen group. .Iaddend. .Iadd. 14. The method of claim 13 wherein the substituent group is a chloro group. .Iaddend..Iadd. 15. The method of claim 1 wherein the substituent group is a methoxy group. .Iaddend..Iadd. 16. The method of claim 1 wherein the substituent group is a tri halomethyl group. .Iaddend..Iadd. 17. The method of claim 1 wherein the compound is a di substituted 2-(phenylmethoxy)phenol compound and wherein one substituent group is a methyl group and another substituted group is a halogen group. .Iaddend..Iadd. 18. The method of claim 1 wherein the compound is a di substituted 2-(phenylmethoxy)phenol compound and both substituent groups are methyl groups. .Iaddend..Iadd. 19. The method of claim 1 wherein the compound is a di substituted 2-(phenylmethoxy)phenol compound and both substituent groups are methoxy groups. .Iaddend..Iadd. 20. The method of claim 1 wherein the compound is a di substituted 2-(phenylmethoxy)phenol compound and one substituted group is a methyl group and another substituted group is a tri halomethyl group. .Iaddend.