Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Abstract

Optionally substituted 1,2,3,5-tetrahydroimidazol[2,1-b]-quinazolin-2-ones and 6-[H]-1,2,3,4-tetrahydropyrimidol[2,1-b]quinazolin-2-ones or the pharmaceutically acceptable salts thereof are compounds useful as blood platelet anti-aggregative and/or antihypertensive and/or bronchodilator agents in mammals, including humans.

We claim: 
     
       1. The compound having the formula ##STR33## in which R 1  is H, phenyl or (lower)alkyl, R 2  and R 3  when different are hydrogen, chloro, bromo, fluoro, CF 3 , SO 3  H, hydroxy, (lower)alkyl or (lower) alkoxy, nitro, amino or phenyl, R 2  and R 3  when alike are hydrogen, bromo, chloro, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2  and R 3  are methylenedioxy or the moiety --CH═CH--CH═CH--, and n is an integer of 1 or 2; or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       2. The compound of claim 1 having the formula ##STR34## in which R 1  is H, phenyl or (lower)alkyl, R 2  and R 3  when different are hydrogen, chloro, bromo, fluoro, CF 3 , SO 3  H, hydroxy, (lower)alkyl or (lower)alkoxy or phenyl, R 2  and R 3  when alike are hydrogen, chloro, bromo, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2  and R 3  are methylenedioxy or the moiety --CH═CH--CH═C--, and n is an integer of 1 or 2; or a pharmaceutically acceptable acid salt thereof. 
     
     
       3. The compound of claim 1 having the formula ##STR35## in which R 1  is H, phenyl or (lower)alkyl, R 2  and R 3  when different are hydrogen, chloro, bromo, CF 3 , SO 3  H, fluoro, hydroxy, nitro, amino, phenyl, (lower)alkyl or (lower)alkoxy, R 2  and R 3  when alike are hydrogen, chloro, bromo, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2  and R 3  are methylenedioxy or the moiety --CH═CH--CH═CH--; or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       4. The compound of claim 3 having the formula ##STR36## in which R 2  and R 3  when different are hydrogen, chloro, bromo, fluoro, nitro, amino, CF 3 , SO 3  H, hydroxy, (lower)alkoxy or (lower)alkyl, R 2  and R 3  when alike are hydrogen, chloro, bromo, fluoro, hydroxy, (lower)alkyl of 1 to 3 carbon atoms or (lower)alkoxy of 1 to 3 carbon atoms, or when taken together R 2  and R 3  are methylenedioxy or the moiety --CH═CH--CH═CH--; or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       5. The compound of claim 2 having the formula ##STR37## in which R 2  and R 3  are alike or different and are H, hydroxy, (lower)alkoxy of 1 to 3 carbon atoms or (lower)alkyl of 1 to 3 carbon atoms, chloro, or fluoro; or a pharmaceutically acceptable salt thereof. 
     
     
       6. The compound of claim 2 having the formula ##STR38## in which R 2  and R 3  are alike or different and each is H, Cl, methoxy, methyl or hydroxy; or the hydrochloride salt thereof. 
     
     
       7. The compound of claim 6 in which R 2  and R 3  are hydrogen; or the hydrochloride salt thereof. 
     
     
       8. The compound of claim 6 in which R 2  and R 3  are methoxy; or the hydrochloride salt thereof. 
     
     
       9. The compound of claim 6 in which R 2  and R 3  are methyl; or the hydrochloride salt thereof. 
     
     
       10. The compound of claim 6 in which R 2  is H and R 3  is methoxy; or the hydrochloride salt thereof. 
     
     
       11. The compound of claim 6 in which R 2  is methoxy and R 3  is hydrogen; or the hydrochloride salt thereof. 
     
     
       12. The compound of claim 6 in which R 2  is hydrogen and R 3  is methyl; or the hydrochloride salt thereof. 
     
     
       13. The compound of claim 6 in which R 2  is methyl and R 3  is hydrogen; or the hydrochloride salt thereof. 
     
     
       14. The compound of claim 4 in which R 2  is nitro and R 3  is methyl; or the hydrochloride salt thereof. 
     
     
       15. The compound of claim 4 in which R 2  and R 3  when taken together are --CH═CH--CH═CH--; or the hydrochloride salt thereof. 
     
     
       16. The compound having the formula ##STR39## or an acid addition salt thereof. 
     
     
       17. The hydrochloride salt of the compound of claim 16. 
     
     
       18. The compound having the formula ##STR40## or an acid addition salt thereof. 
     
     
       19. The hydrochloride salt of the compound of claim 18. .Iadd. 20. The compound having the formula ##STR41## 
     
     
        or an acid addition salt thereof. .Iaddend..Iadd. 21.  The compound having the formula ##STR42## 
     
     
        or an acid addition salt thereof. .Iaddend..Iadd. 22.  The compound having the formula ##STR43## 
     
     
        or an acid addition salt thereof. .Iaddend..Iadd. 23.  The compound having the formula ##STR44## 
     
     
        or an acid additon salt thereof. .Iaddend..Iadd. 24.  The compound having the formula ##STR45## 
     
     
        or an acid addition salt thereof. .Iaddend..Iadd. 25.  The compound having the formula ##STR46## or an acid addition salt thereof. .Iaddend.