Radiopharmaceutical chelates and method of external imaging

Abstract

A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and substituted iminodiacetic acid or an 8-hydroxyquinoline useful as a radiopharmaceutical external imaging agent. The invention also includes preparative methods therefor.

We claim: 
     
       1. A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and a substituted iminodiacetic acid .[...]..Iadd., said chelate, upon intravenous administration, being liver and/or gallbladder selective..Iaddend. .[.2. A chelate of technetium-99m cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and an 
     
     
        8-hydroxyquinoline..]. 3. A composition comprising a mixture of the technetium-99m chelate of claim 1 and the stannous chelate of said 
     
     
        chelating agent. 4. A composition comprising a mixture of the technetium-99m chelate of claim 1, the stannous chelate of said chelating 
     
     
        agent and said chelating agent. 5. The chelate of claim 1 wherein said iminodiacetic acid chelating agent is N-methyliminodiacetic acid, N-[N'-(2,6-dimethylphenyl) carbamoylmethyl] iminodiacetic acid, N-(10-carboxydecyl) iminodiacetic acid, N-(O-bromobenzyl) iminodiacetic acid, N-[3-(1-naphthyloxy)-2-hydroxypropyl] iminodiacetic acid, 
     
     
        .[.nitrilo-triacetic acid.]. or 2,6-pyridinedicarboxylic acid. 
     
     
        6. N-[N'(2,6-dimethylphenyl) carbamoylmethyl] iminodiacetic acid. 7. A method of external imaging which includes the intravenous administration of a solution adapted for intravenous administration containing the chelate of claim 1.  .[.8. A method of external imaging which includes the intravenous administration of a solution adapted for intravenous 
     
     
        administration containing the chelate of claim 2..]. 9. A method of preparing the chelate of claim 1 comprising reacting said radio-isotope 
     
     
        with said chelating agent. 10. The method of claim 9 wherein said 
     
     
        radioisotope is technetium-99m. 11. The method of claim 10 wherein said chelate is prepared by reducing a pertechnetrate in the presence of said 
     
     
        chelating agent. 12. The method of claim 11 wherein said reduction is effected utilizing stannous chloride as a reducing agent.  .[.13. A method of preparing the chelate of claim 2 comprising reacting said radio-isotope with said chelating agent..]..Iadd. 14. A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and 5,7-diiodo-8-hydroxyquinoline. .Iaddend..Iadd. 15. A method of external imaging which includes the intravenous administration of a solution adapted for intravenous administration and containing the chelate of claim 14. .Iaddend..Iadd. 16. A method of preparing the chelate of claim 14 comprising reacting said radio-isotope with said chelating agent. .Iaddend. .Iadd. 17. A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and a substituted iminodiacetic acid of the formula: .Iaddend. ##STR2## .Iadd.wherein R may be alkyl having up to 14 carbon atoms. .Iaddend..Iadd. 
     
     
        8.  A composition comprising a mixture of the technetium-99m chelate of claim 17 and the stannous chelate of said chelating agent. .Iaddend..Iadd. 19. A composition comprising a mixture of the technetium-99m chelate of claim 17, the stannous chelate of said chelating agent and said chelating agent. .Iaddend..Iadd. 20. A method of external imaging which includes the intravenous administration of a solution adapted for intravenous administration containing the chelate of claim 17. .Iaddend..Iadd. 21. A method of preparing the chelate of claim 17 comprising reacting said radio-isotope with said chelating agent. .Iaddend. .Iadd. 22. A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and N-[N'-(2,6-dimethylphenyl) carbamoylmethyl] iminodiacetic acid. .Iaddend. .Iadd. 23. A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and methyliminodiacetic acid. .Iaddend..Iadd. 24. A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and 10-carboxydecyliminodiacetic acid. .Iaddend..Iadd. 25. A chelate of technetium-99m, cobalt-57, galium-67, gallium-68, indium-111 or indium-113m and N-(o-bromobenzyl) iminodiacetic acid. .Iaddend..Iadd. 26. A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and 2,6-pyridinedicarboxylic acid. .Iaddend..Iadd. 27. A chelate of claim 1 wherein said radioisotope is technetium-99m. .Iaddend.