Non-wicking polyurethane casting systems

Abstract

A non-wicking polyurethane casting system has been developed which comprises the reaction product obtained by admixing a polyol containing N-N-N'-N'-tetrakis (2-hydroxypropyl) ethylene diamine, (hereafter referred to as QUADROL) with an isocyanate terminated polyurethane based prepolymer. This non-wicking casting system is useful as a potting compound in biomedical applications such as dialysis and hemoultrafiltration devices and the like.

It is claimed: 
     
       1. A hollow fiber separatory device capable of use in biomedical applications comprising a hollow fiber bundle consisting of a plurality of fine hollow fibers whose end portions are potted in a tube-sheet and whose open fiber ends terminate in a tube-sheet face, the resulting bundle being sealed within a casing to form a separatory cell having .[.one.]. .Iadd.two .Iaddend.or more fluid ports which allow for the passage of one fluid through the fibers and another around the fibers without mixing of the two fluids, said tube-sheet comprising a cured polyurethane composition comprising the reaction product of (1) a polyol mixture of (a) at least one polyol, and (b) N-N-N'-N'-tetrakis (2-hydroxypropyl) ethylene diamine, and (2) an isocyanate terminated polyurethane based prepolymer, said diamine being present in said polyol mixture in an amount sufficient to cause the viscosity of the urethane system to increase rapidly upon mixing of said polyol containing mixture and said prepolymer to form a gel which turns to a solid upon standing without markedly increasing the initial mix viscosity of the urethane system, thereby permitting placement of said urethane system and substantially reducing wicking of said urethane system after placement, said amount providing a ratio of equivalents of the N-N-N'-N'-tetrakis (2-hydroxypropyl) ethylene diamine to the polyol of from 5:95 to 40:60, and said polyol and said prepolymer being reacted in amounts to provide an NCO-OH equivalent ratio of about 1 to 1.1:1. 
     
     
       2. The device of claim 1 wherein the isocyanate terminated prepolymer is derived from an aromatic diisoyanate selected from the group consisting of 4-4'diphenylmethane diisocyanate, polymethylene polyphenylisocyanate, 1,5-naphthalene diisocyanate and phenylene diisocyanate. 
     
     
       3. The device of claim 1 wherein the isocyanate terminated prepolymer is derived from a cycloaliphatic diisocyanate selected from the group consisting of 3-isocyanato methyl, 3,5,5-trimethylcyclohexyl isocyanate and 4,4'-methylene bis (cyclohexyl isocyanate). .Iadd. 4. A biomedical separatory device comprising a semi-permeable membrane separating means whose extremities are potted in a holding means, the resulting separating means being sealed by the holding means to a casing to form a separatory cell having two or more fluid ports which allow passage of one fluid on one side of the separating means and another fluid on the other side of said separating means without mixing of the two fluids, said holding means comprising a cured polyurethane composition comprising the reaction product of (1) a polyol mixture of (a) at least one polyol, and (b) N-N-N'-N'-tetrakis (2-hydroxypropyl) ethylene diamine, and (2) an isocyanate terminated polyurethane based prepolymer, said diamine being present in said polyol mixture in an amount sufficient to cause the viscosity of the urethane system to increase rapidly upon mixing of said polyol containing mixture and said prepolymer to form a gel which turns to a solid upon standing without markedly increasing the initial mix viscosity of the urethane system, thereby permitting placement of said urethane system and substantially reducing wicking of said urethane system after placement, said amount providing a ratio of equivalents of the N-N-N'-N'-tetrakis (2-hydroxypropyl) ethylene diamine to the polyol of from 5:95 to 40:60 and said polyol and said prepolymer being reacted in amounts to provide an NCO-OH equivalent ratio of about 1:1 to 1.1:1. .Iaddend..Iadd. 5. The device of claim 4 wherein said semi-permeable membrane separating means comprises a plurality of fine hollow fibers, said holding means is a tube sheet, and the end portions of said fibers are potted in said tube sheet and the open fiber ends terminate in a face of said tube sheet. .Iaddend..Iadd. 6. The device of claim 4 wherein said semi-permeable membrane separating means comprises a membrane having a plurality of folds, the outer edges of said membrane and the tips of said folds are potted in said holding means to said casing. .Iaddend.  .Iadd. 7. The device of claim 4 wherein the isocyanate terminated prepolymer is derived from an aromatic diisocyanate selected from the group consisting of 4-4' diphenyl methane diisocyanate, polymethylene polyphenylisocyanate, 1,5-naphthalene diisocyanate, phenylene diisocyanate and tolylene diisocyanate and mixtures thereof. .Iaddend..Iadd. 8. The device of claim 4 wherein the isocyanate terminated prepolymer is derived from a cycloaliphatic diisocyanate selected from the group consisting of 3-isocyanato methyl, 3,5,5-trimethylcyclohexyl isocyanate, 4,4'-methylene bis (cyclohexyl isocyanate), hexamethylene diisocyanate and mixtures thereof. .Iaddend.