Indolo isoquinoline compounds

Abstract

Isoquinoline compounds of the following formula are described: ##STR1## wherein the moiety A-B represents a group of formula: --CH 2 --NR 3 -- or --NR 3 --CH 2 --; wherein R 3 represents hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl C 3-6 cycloalkyl-C 1-4 alkyl, optionally substituted benzyl, C 3-6 alkenyl or C 1-4 alkanoyl; wherein R represents hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, or optionally substituted benzyl; wherein R 1 and R 2 each represent hydrogen or taken together represent a chemical bond; and wherein X is hydrogen or halogen; or an acid-addition salt thereof. The compounds are pharmaceuticals and especially useful in the treatment of disorders of the central nervous system.

We claim: 
     
       1. A compound of the formula: ##STR11## where the moiety D-E represents a group of the formula: ##STR12## wherein R 3  represents hydrogen, C 1-6  alkyl, C 3-6  cycloalkyl, C 3-6  cycloalkyl-C 1-4  alkyl, benzyl, benzyl substituted with from 1-3 of the following substituents: halogen, methyl, methoxy, nitro; C 3-6  alkenyl or C 1-4  alkanoyl; wherein R represents hydrogen, C 1-6  alkyl, C 3-6  cycloalkyl, benzyl, benzyl substituted with from 1-3 of the following substituents: halogen, methyl, methoxy, nitro; and   wherein R 1  and R 2  when D-.Iadd.E is ##STR13##.Iaddend. each represent hydrogen .Iadd.and when D-E is ##STR14##.Iaddend. represent hydrogen when taken singly, or taken together represent a chemical bond.