Pharmacologically active compounds

Abstract

The compounds are substituted S-(aminoalkyl)-isothioureas which are histamine H 2 -antagonists. Two specific compounds of the present invention are S-[6-(N'-methylthioureido)hexyl]isothiourea and S-[5-(N'-cyano-N"-methylguanidino)pentyl]isothiourea.

What is claimed is: 
     
       1. A compound of the formula ##STR8## wherein n is an integer from 3 to 6; R is lower alkyl .[.or.]. ##STR9## X is sulphur; or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       2. A compound of claim 1 wherein n is 5 or 6. 
     
     
       3. A compound of claim 1, said compound being a salt of S-[6-(N'-methylthioureido)hexyl]isothiourea. 
     
     
       4. A compound of claim 1, said compound being a salt of S-[5-(N'-methylthioureido)pentyl]isothiourea. 
     
     
       5. A compound of claim 1 which is in the form of a pharmaceutically acceptable acid addition salt. 
     
     
       6. A pharmaceutical composition.Iadd., in the form of a tablet, capsule or sterile injectable liquid, .Iaddend.to block histamine H 2  -receptors comprising in an effective amount to block said receptors a compound of .[.claim 1.]. .Iadd.the formula: ##STR10##.Iaddend. wherein n is an integer from 3 to 6; R is lower alkyl or ##STR11## and X is sulphur in the form of a pharmaceutically acceptable acid addition salt in combination with a pharmaceutically acceptable diluent or carrier. 
     
     
       7. A pharmaceutical composition of claim 6 in unit dosage form for oral administration. 
     
     
       8. A method of blocking histamine H 2  -receptors which comprises administering to an animal in need thereof in an effective amount to block said receptors a compound of .[.claim 1.]. .Iadd.the formula: ##STR12##.Iaddend. and X is sulphur; or a pharmaceutically acceptable acid addition salt thereof. 
     
     
       9. A method of treating inflammation which comprises administering to an animal in need thereof in an effective amount to treat inflammation a compound of .[.claim 1.].  .Iadd.the formula: ##STR13##.Iaddend. wherein n is an integer from 3 to 6; R is lower alkyl or ##STR14## and X is sulphur; or a pharmaceutically acceptable acid addition salt thereof.