Treatment of genital tract diseases of domestic animals with prostaglandins

Abstract

The treatment of purulent diseases of the female genital track of domestic animals by administration of an amount of a domestic animal luteolytic-uterine smooth muscle stimulating prostaglandin (DALUSMUS-PG) effective to cure said disease is disclosed.

I claim: .[.1. A method for treating a female domestic animal suffering from a purulent genital tract disease which comprises: 
     
        disease..]. .[.3.  A method according to claim 2 wherein said purulent genital tract disease is endometritis..]. .[.4. A method according to claim 2 wherein said purulent genital tract disease is metritis..]. .[.5. A method according to claim 2 wherein said purulent genital tract disease is mucometra..]. .[.6. A method according to claim 2 wherein said genital tract disease is pyometra..]. .[.7. A method according to claim 6 wherein said female domestic animal is bovine, equine, or swine..]. .[.8. A method according to claim 6 wherein said domestic animal is canine or feline..]. .[.9. A method according to claim 8 wherein said DALUSMUS-PG is 15-methyl-PGF 2 α, THAM salt..]. .[.10. A method according to claim 8, wherein said DALUSMUS-PG is PGF 2 α, THAM salt or PGF 2 α, 1-arginine salt..]. .[.11. A method according to claim 1 wherein said DALUSMUS-PG is at least as potent as PGF 2 α in a gerbil colon smooth muscle assay or a hamster anifertility assay..]. .[.12. A method according to claim 1 wherein said DALUSMUS-PG is at least as potent as PGF 2 α in both a gerbil colon smooth muscle assay and a hamster antifertility assay..]. .[.13. A method according to claim 12 wherein said purulent genital tract disease is endometritis..]. .[.14. A method according to claim 12 wherein said purulent genital tract disease is metritis..]. .[.15. A method according to claim 12 wherein said purulent genital tract disease is mucometra..]. .[.16. A method according to claim 12 wherein said genital tract disease is pyometra..]. .[.17. A method according to claim 16 wherein said female domestic animal is bovine, equine, or swine..]. .[.18. A method according to claim 16 wherein said domestic animal is canine or feline..]. .[.19. A method according to claim 18 wherein said DALUSMUS-PG is 15-methyl-PGF 2 α, THAM salt..]. .[.20. A method according to claim 18 wherein said DALUSMUS-PG is PGF 2 α, THAM salt or PGF 2 α, 1-arginine salt..]. .Iadd. 21. A method for treating a female domestic dog or cat suffering from a purulent genital tract disease which comprises: administering to said dog or cat an amount of a domestic animal luteolytic-uterine smooth muscle stimulating prostaglandin (DALUSMUS-PG) effective to cure said disease. .Iaddend..Iadd. 22. A method according to claim 21, wherein said DALUSMUS-PG is at least as potent as PGF 2 α in a gerbil colon smooth muscle assay or a hamster antifertility assay. .Iaddend. .Iadd. 23. A method according to claim 21, wherein said DALUSMUS-PG is at least as potent as PGF 2 α in both a gerbil colon smooth muscle assay and a hamster antifertility assay. .Iaddend..Iadd. 24. A method according to claim 23, wherein said purulent genital tract disease is endometritis. .Iaddend..Iadd. 25. A method according to claim 23, wherein said purulent genital tract disease is metritis. .Iaddend..Iadd. 26. A method according to claim 23, wherein said purulent genital tract disease is mucometra. .Iaddend..Iadd. 27. A method according to claim 23, wherein said genital tract disease is pyometra. .Iaddend..Iadd. 28. A method according to claim 27, wherein said DALUSMUS-PG is 15-methyl-PGF 2 α, THAM salt. .Iaddend..Iadd. 29. A method according to claim 27, wherein said DALUSMUS-PG is PGF 2 α, THAM salt or PGF 2 α, 1-arginine salt..Iaddend.