Substituted pyrroloquinoxalinones and diones

Abstract

Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.

I claim: .[.1. A method of treating vascular thrombosis according to the method of claim 2 in mammals which comprises administering to a mammal in need of such treatment an amount of 6-phenyl-1H-pyrrolo-[1,2,3-de]quinoxalin-2,5[3H,6H]-dione effective for treating vascular thrombosis..]. .[.2. A method of treating vascular thrombosis in mammals which comprises administering to a mammal in need of such treatment an amount of a compound of the formula effective for treating vascular thrombosis..]. ##STR5## .[.wherein 
     
        C 1  -C 3  alkyl..]. .Iadd. 3.  A method of treating vascular thrombosis in mammals which comprises administering to a mammal in need of such treatment an amount of a compound of the formula effective for treating vascular thrombosis. ##STR6## wherein R 1  is H or C 1  -C 3  alkyl; when taken singly, R 2  is H, C 1  -C 3  alkyl, C 1  -C 3  alkoxy, F or Cl and R 3  is H; and   R 2  and R 3  when taken together with the carbon atoms to which they are attached form a benzene ring;   R 4  is H, Cl or F;   R 5  is OH, H or phenyl;   Y is O or H 2  ;   Z is --CH 2  --CH 2  -- or --CHR 6  -- wherein R 6  is H or   
     
     
        C 1  -C 3  alkyl. .Iaddend. .Iadd. 4.  A method of treating vascular thrombosis according to the method of claim 3 in mammals which comprises administering to a mammal in need of such treatment an amount of 6-phenyl-1H-pyrrolo-[1,2,3-de]-quinoxalin-2,5 [3H,6H]-dione effective for treating vascular thrombosis. .Iaddend.