Substituted pyrroloquinoxalinones and diones

Abstract

Substituted pyrroloquinoxalinones and diones, useful as anti-inflammatory and anti-thrombotic agents.

I claim: 
     
       1. A compound of the formula: ##STR5## wherein R' is H or C 1  -C 3  alkyl; when taken singly, R 2  is H, C 1  -C 3  alkyl, C 1  -C 3  alkoxy, .Iadd.F .Iaddend.or Cl and R 3  is H; and   R 2  and R 3  when taken together with the carbon atoms to which they are attached form a benzene ring;   R 4  is H, Cl or F;   R 5  is OH, H or phenyl;   Y is O or H 2  ;   Z is --CH 2  --CH 2  -- or --CHR 6  -- wherein R 6  is H or C 1  -C 3  alkyl.   
     
     
       2. A compound according to claim 1 in which R', R 2 , R 3 , R 4  and R 5  are H, Z is CHR 6 , R 6  is H and Y is O, said compound being 6-phenyl-1H-pyrrolo[1,2,3-de]quinoxalin-2,5(3H,6H)-dione. 
     
     
       3. A compound according to claim 1 in which R', R 2 , R 3 , R 4  and R 5  are H, Z is CHR 6 , R 6  is C 1  -C 3  alkyl and Y is O. 
     
     
       4. A compound according to claim 3 in which R 6  is ethyl, said compound being 3-ethyl-6-phenyl-1H-pyrrolo-[1,2,3de]quinoxalin-2,5(3H,6H)-dione. 
     
     
       5. A compound according to claim 3 in which R 6  is methyl, said compound being 3-methyl-6-phenyl-1H-pyrrolo-[1,2,3-de]quinoxalin-2,5(3H,6H)-dione. 
     
     
       6. A compound according to claim 1 in which R' is C 1  -C 3  alkyl, R 2 , R 3 , R 4  and R 5  are H, Z is CHR 6 , R 6  is H and Y is O. 
     
     
       7. A compound according to claim 6 in which R' is methyl, said compound being 1-methyl-6-phenyl-1H-pyrrolo-[1,2,3-de]quinoxalin-2,5(3H,6H)-dione. 
     
     
       8. A compound according to claim 6 in which R' is ethyl, said compound being 1-ethyl-6-phenyl-1H-pyrrolo-[1,2,3-de]quinoxalin-2,5(3H,6H)-dione.