USRE29935EExpiredUtility

N-Substituted imidazoles and their salts

23
Priority: Nov 29, 1968Filed: Jan 27, 1978Granted: Mar 13, 1979
Est. expiryNov 29, 1988(expired)· nominal 20-yr term from priority
C07D 401/10
23
PatentIndex Score
2
Cited by
5
References
21
Claims

Abstract

Certain imidazoles and their salts having fungistatic properties are provided which have the following basic structure: ##STR1## in which Y is --(CH 2 ) n --, --CH═CH--, O or S; A is N or CH; and n is 0, 1 or 2. Typical fungi are trichophyton species, Microsporon species, Candida species and Penicillium species. These compounds are also active against pathogenic protozoa, viruses and bacteria.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. An N-substituted imidazole of the formula: ##STR10## in which X is alkyl of 1 to 4 carbon atoms, mercaptoalkyl of 1 to 4 carbon atoms in the alkyl moiety, halogen, nitro, cyano or trifluoromethyl, Y is --(CH 2 ) n  -- or --CH═CH--,   A is CH,   m is 0 or 1 and   n is 0, 1 or 2, or a pharmaceutically acceptable salt thereof.     
     
     
       2. The compound of claim 1 which is ##STR11## 
     
     
       3. The compound of claim 1 which is ##STR12## 
     
     
       4. The compound of claim 1 which is ##STR13## 
     
     
       5. The compound according to claim 1, wherein X .[.if.]. .Iadd.is .Iaddend.4-F, .Iadd.Y is --(CH 2 ) n  -- wherein n is 0, .Iaddend.A is CH and m is 1. 
     
     
       6. The compound according to claim 1, wherein X is 4-Cl, .Iadd.Y is --(CH 2 ) n  -- wherein n is 0, .Iaddend.A is CH and m is 1. 
     
     
       7. The compound according to claim 1, wherein X .[.if.]. .Iadd.is .Iaddend.4-Br, .Iadd.Y is --(CH 2 ) n  -- wherein n is 0, .Iaddend.A is CH and m is 1. 
     
     
       8. The compound according to claim 1, wherein X is 4-SCH 3 , .Iadd.Y is --(CH 2 ) n  -- wherein n is 0, .Iaddend.A is CH and m is 1. 
     
     
       9. The compound according to claim 1, wherein X is 3-Cl, .Iadd.Y is --(CH 2 ) n  -- wherein n is 0, .Iaddend.A is CH and m is 1. 
     
     
       10. The compound according to claim 1, wherein X is 2-Cl, .Iadd.Y is --(CH 2 ) n  -- wherein n is 0, .Iaddend.A is CH and m is 1. 
     
     
       11. The compound according to claim 1, wherein X is 4-F, Y is --(CH 2 ) 2  --, A is CH and m is 1. 
     
     
       12. The compound according to claim 1, wherein X is 4-F, Y is --CH═CH--, A is CH and m is 1. 
     
     
       13. The compound according to claim 1, wherein X is 4-Cl, Y is --CH═CH--, A is CH and m is 1. 
     
     
       14. The compound according to claim 1, wherein X is 4-Br, Y is --CH═CH--, A is CH and m is 1. 
     
     
       15. The compound according to claim 1, wherein X is 2-Cl, Y is --CH═CH--, A is CH and m is 1. 
     
     
       16. The compound according to claim 1, wherein X is 3-CF 3 , Y is --CH═CH--, A is CH and m is 1. 
     
     
       17. The compound according to claim 1, wherein X is 3-Cl, Y is --CH═CH--, A is CH and m is 1. 
     
     
       18. The compound according to claim 1, wherein X is 3-CF 3 , Y is --CH 2  --CH 2  --, A is CH and m is 1. 
     
     
       19. The compound according to claim 1, wherein X is 3-CF 3 , Y is --CH 2  --CH 2  --, A is CH and m is 1. 
     
     
       20. The compound according to claim 1, wherein X is 4-SCH 3 , Y is --CH 2  --CH 2  --, A is CH and m is 1. 
     
     
       21. The compound according to claim 1, wherein X is 2-CH 3 , .Iadd.Y is --(CH 2 ) n  -- wherein n is 0, .Iaddend.A is CH and m is 1.

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