Antibacterial antibiotics AM31α, AM31β and AM31γ

Abstract

This disclosure describes a novel class of antibiotics, three of which have been designed AM31α, AM31β, and AM31γ and are produced in a microbiological fermentation under controlled conditions using a new strain of Streptoverticillium netropsis.

We claim:  .[.1. A compound selected from the group consisting of those of the formula: ##STR6## wherein R is selected from the group consisting of hydrogen, formyl, and alkanoyl having up to 12 carbon atoms; and the pharmaceutically acceptable 
     
        acid-addition salts thereof..]. .[.2.  A compound according to claim 1 wherein R is hydrogen..]. .[.3. A compound according to claim 1 wherein R is formyl..]. .[.4. A compound according to claim 1 wherein R is acetyl..]. .[.5. A compound according to claim 1 wherein R is propionyl..]. .[.6. A compound according to claim 1 wherein R is butyryl..]. .[.7. A compound according to claim 1 wherein R is octanoyl..]. .[.8. A compound acording to claim 1 wherein R is dodecanoyl..]. .[.9. The antibiotic free base according to claim 2..]. .[.10. The antibiotic free base according to claim 3..]. .[.11. The antibiotic free base according to claim 4..]. .[.12. The antibiotic free base according to claim 5..]. .[.13. The antibiotic free base according to claim 6..]. .[.14. The antibiotic free base according to claim 7..]. .[.15. The antibiotic free base according to claim 8..]. .Iadd. 16. A compound selected from the group consisting of the antibiotic free base of the formula: ##STR7## and the pharmaceutically acceptable acid-addition salts thereof. 
     
     
        .Iaddend..Iadd. 17.  A compound selected from the group consisting of the antibiotic free base of the formula: ##STR8## and the pharmaceutically acceptable acid-addition salts thereof. .Iaddend.