6-Aryloxy-2-oxo-1-aza-4-oxo (or thia)-spiro[4,5]decanes as CNS stimulants

Abstract

6-Aryloxy-2-oxo-1-aza-4-oxa (or thia)-spiro[ 4,5]decane compounds. These compounds are represented by the formula ##STR1## in which A stands for an oxygen or sulfur heteroatom; R 1 and R 2 are each H, lower alkyl or aryl such as phenyl; X is H, a halogen atom such as chlorine or fluorine or a lower alkyl. Compounds according to the invention are useful as stimulating agents for vigilance, as psycho-stimulators and genesic stimulators.

What is claimed is: 
     
       1. A compound of the formula: ##STR10## in which R 1  and R 2  respresent each, independently from one another, a member selected from the group consisting of hydrogen, a lower alkyl or phenyl; X is hydrogen, a halogen atom or a lower alkyl. 
     
     
       2. A compound according to claim 1, wherein R 1  represents a phenyl group. 
     
     
       3. A compound according to claim 1, wherein R 2  represents a phenyl group. 
     
     
       4. A compound according to claim 1, wherein X is chlorine or fluorine. 
     
     
       5. A compound according to claim 1, which is selected amongst the following compounds: 6-(4-fluoro)phenoxy-3,3-dimethyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(3-methyl)phenoxy-3-methyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(3-methyl)phenoxy-3-phenyl-2-oxo-1-aza-4oxa-spiro[4.5[decane,   6-(3-chloro)phenoxy-3-phenyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(3-chloro)phenoxy-3-methyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(4-methyl)phenoxy-3-methyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(4-methyl)phenoxy-3,3-dimethyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(3-methyl)phenoxy-3,3-dimethyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(4-fluoro)phenoxy-3-methyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(4-chloro)phenoxy-3-phenyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(4-chloro)phenoxy-3,3-dimethyl2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-phenoxy-3-methyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane,   6-(3-chloro)phenoxy-3,3-dimethyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane, and   6-(4-chloro)phenoxy-3-methyl-2-oxo-1-aza-4-oxa-spiro[4.5]decane.   
     
     
       6. A central nervous system stimulating composition, which comprises, as active ingredient, an effective amount of a compound as defined in claim 1, in combination with a pharmaceutically acceptable vehicle. 
     
     
       7. A method for stimulating the central nervous system which comprises administering to the patient an effective amount of a compound as described in claim 1.