Triamcinolone acetonide derivative

Abstract

.[.Triamcinolone.]. .Iadd.Bis(triamcinolone .Iaddend.acetonide.Iadd.) .Iaddend.4,4'-methylene-bis(3-methoxy-2-naphthoate), method of preparing the same by preparing a reactive derivative of 4,4'-methylene-bis(3-methoxy-2-naphthoic) acid and reacting such derivative with triamcinoline acetonide. The triamcinolone acetonide derivative is particularly suitable for use in the treatment of dermatosis, eczema, neurodermatitis, impetigo, psoriasis, pruritis, erythema and the like.

I claim: 
     
       1. A pharmaceutical preparation comprising as active ingredients .[.triamcinolone acetonide.].  .Iadd.bis(triamcinolone acetonide).Iaddend.4,4'-methylene-bis(3-methoxy-2-naphthoate); and a pharmaceutically acceptable carrier. 
     
     
       2. A pharmaceutical preparation according to claim 1 in the form of a cream. 
     
     
       3. A pharmaceutical preparation according to claim 2 wherein said active ingredient is present in an amount of 0.1 to 0.5 percent. 
     
     
       4. A method of treating allergic and inflammatory dermatoses which comprises applying to affected areas of the skin a therapeutically effective amount of a pharmaceutical preparation according to claim 1. 
     
     
       5. A method according to claim 4 which comprises applying said pharmaceutical preparation as 0.1 to 0.5 percent cream 2 or 3 times daily. 
     
     
       6. A method of treating arthritis, bursitis, tendinitis and synovitis which comprises administering to the patient having such condition a therapeutically effective amount of a pharmaceutical preparation according to claim 1.