Derivatives of 5-hydroxymethyl-3-substituted-2-oxazolidinones, process of preparation thereof and therapeutic application

Abstract

Compounds of the formula ##STR1## in which R is H, .[.Cl, F, CH 3 or CF 3 .]. .Iadd.m-F, p-F, o-F, p-Cl, p-CH 3 , m-CH 3 or m-CF 3 .Iaddend.. The compounds are prepared by cyclizing with ethyl carbonate, a compound of the formula ##STR2## The compounds have anti-depressive, myorelaxing, tranquilizing, sedative, analgesic, anti-convulsive, anti-pyretic, anti-inflammatory and uricosuric activities.

What we claim is: .[.1. A compound of the formula .Iadd. ##STR6##.Iaddend. in which R is selected from the group consisting of hydrogen, 
     
        chlorine, fluorine, methyl and trifluoromethyl..]. .[.2.  A compound as claimed in claim 1, in which R is chlorine or fluorine..]..Iadd. 3. A compound of the formula .Iadd. ##STR7## 
     
     
       .Iaddend.  .Iadd. 4.  A compound of the formula .Iadd. ##STR8## 
     
     
       .Iaddend.  .Iadd. 5.  A compound of the formula  .Iadd. ##STR9##.Iaddend. in which R is selected from the group consisting of p-methyl and 
     
     
        m-methyl.  .Iadd. 6.  A compound of the formula .Iadd. ##STR10## 
     
     
       .Iaddend.  .Iadd. 7.  A compound of the formula .Iadd. ##STR11##.Iaddend.