Method for preparing acylated products

Abstract

Acylation of nitrogen containing compounds utilizing esters as acylation agents in the presence of salts of substituted pyridine compounds.

What is claimed is: 
     
       1. In the process for preparing a carboxylic acid amide wherein a primary or secondary amine selected from alkylamines, arylamines and substituted arylamines is acylated with an ester derived from aliphatic or aromatic carboxylic acid, the improvement which comprises carrying out said acylation in the presence of an alkali-metal salt, an alkaline earth metal salt .[.of.]. .Iadd.or .Iaddend.a quaternary ammonium salt of a compound containing a pyridine nucleus directly substituted by a hydroxy group .[.,.]. .Iadd.or .Iaddend.a mercapto group, .[.or a group selected from.]. .Iadd.and optionally by at least one member selected from the group consisting of .Iaddend.alkyl groups having 1 to 6 carbon atoms, aryl groups, aralkyl groups, .Iadd.lower .Iaddend.alkoxy groups .[.having 1 to 6 carbon atoms.]. , nitro groups, .[.and.]. cyano groups .Iadd.and an unsubstituted benzene ring which is fused to the pyridine nucleus.Iaddend.. 
     
     
       2. The process of claim 1 wherein the compound containing the pyridine nucleus is .[.a.]. quinoline or .[.an.]. isoquinoline. 
     
     
       3. The process of claim 1 wherein the carboxylic acid amide is benzyloxycarbonyl-L-valinebenzylamide. 
     
     
       4. The process of claim 1 wherein the salt is the sodium salt of 2-hydroxy pyridine. .Iadd. 
     
     
       5.  The process of claim 1 wherein said lower alkoxy group is methoxyl or ethoxyl..Iaddend.