N-Substituted aspartyl peptide amides

Abstract

Peptides containing the residues of methionine and aspartic acid are prepared by standard coupling techniques and display valuable pharmacological, e.g. gastrin-inhibitory, properties.

What is claimed is: 
     
       1. A compound of the formula ##STR2## wherein X is hydrogen or a tertiary-butoxycarbonyl radical, Y is a tryptophanyl radical, n is 0 or 1 and Z is an amine residue wherein the amine is an alkyl amine, cycloalkyl amine, or heterocyclic amine .[.or aralkyl amine.].. 
     
     
       2. As in claim 1, the compound which is N-tertiary-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-α-aspartyl-DL-2'-phenylcyclopropylamide. 
     
     
       3. The compound N-tertiary-butoxycarbonyl-L-methionyl-L-α-aspartyl-DL-1-methylphenoxyethylamide. 
     
     
       4. The compound N-tertiary-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-α-aspartyl-DL-1-methyl-4'-fluorophenethylamide. 
     
     
       5. The compound N-tertiary-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-α-aspartyl-DL-1-methylphenoxyethylamide. 
     
     
       6. The compound L-tryptophanyl-L-methionyl-L-α-aspartyl-DL-1-methyl-4'-fluorophenethylamide. 
     
     
       7. The compound L-tryptophanyl-L-methionyl-L-α-aspartyl-DL-1-methylphenoxyethylamide. 
     
     
       8. As in claim 1, the compound which is N-tertiary-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-α -aspartyl-DL-1-methylhexylamide. 
     
     
       9. As in claim 1, the compound which is N-tertiary-butoxycarbonyl-L-methionyl-L-α-aspartyl-2-indanylamide. .[. 
     
     
       10.  As in claim 1, the compound which is N-tertiary-butoxycarbonyl-D-tryptophanyl-L-methionyl-L-α-aspartyl-L-1-methylphenethylamide..]. .[.11. As in claim 1, the compound which is L-tryptophanyl-L-methionyl-L-α-aspartyl-L-1-methylphenethylamide..]. 
     
     
        2. As in claim 1, the compound which is N-tertiary-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-α-aspartyl-L- 
     
     
       1-methylcyclohexylethylamide. 13. As in claim 1, the compound which is N-tertiary-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-α-aspartyltryptamide.