7-Amino-cephalosporanic and decephalosporanic acid derivatives

Abstract

7[D-(-)-α-amino-α-(p-hydroxyphenyl)-acetamido]-cephalosporanic acid and 7-D-(-)-2,2-dimethyl-4-(p-hydroxyphenyl)-5-oxo-1-imidazolidinyl]cephalosporanic acid and the corresponding decephalosporanic acids and the salts thereof are new synthetic compounds of value as antibacterial agents and in the treatment of bacterial infections.

I claim: .[.1. A compound selected from the group consisting of: 
     
        triethylamine salt of the compound of claim 2..]. 7. The compound of claim .[.1.].  .Iadd.14 .Iaddend.named: 3-methyl-7-[D-(-)-α-amino-α-(p-hydroxyphenyl)-acetamido]decepha   
     
     
       losporanic acid. 8. A nontoxic, pharmaceutically acceptable salt of the 
     
     
        compound of claim 7. 9. The sodium salt of the compound of claim 7. 
     
     
        10. The potassium salt of the compound of claim 7. 11. The triethylamine salt of the compound of claim 7. .[.12. The compound of claim 1 named: 7-[D-(-)-2,2-dimethyl-4-(p-hydroxyphenyl)-5-oxo-1-imidazolidinyl]cephalospo   
     
     
       ranic acid and its nontoxic, pharmaceutically acceptable salts..]. 13. The compound of claim .[.1.]. .Iadd.14 .Iaddend.named: 3-methyl-7-[D-(-)-2,2-dimethyl-4-(p-hydroxyphenyl)-5-oxo-1-imidazolidinyl]decephalosporanic acid and its nontoxic, pharmaceutically acceptable salts. .Iadd. 14. A compound selected from the group consisting of:   7-[D-(-)-α-amino-α-(p-hydroxyphenyl)-acetamido]decephalosporanic acid,   7-[D-(-)-2,2-dimethyl-4-(p-hydroxyphenyl)-5-oxo-1-imidazolidinyl]cephalosporanic acid, and   7-[D-(-)-2,2-dimethyl-4-(p-hydroxyphenyl)-5-oxo-1-imidazolidinyl]decephalosporanic acid, and the non-toxic, pharmaceutically acceptable salts thereof. .Iaddend..Iadd. 15. The compound of claim 14 named:   7-[D-(-)-2,2-dimethyl-4-(p-hydroxyphenyl)-5-oxo-1-imidazolidinyl]cephalosporanic acid and its non-toxic, pharmaceutically acceptable salts. .Iaddend.