Contraception agent

Abstract

A spermicidally-active suppository having advantageous properties comprising spermicide, a water-soluble polyethylene glycol suppository base, foaming agent, and foam-stabilizing agent, having a relatively low percentage by weight of foam-developing agent, wherein the spermicide is in alkylphenoxypolyethoxyethanol, the suppository base comprising about 65 to 85 percent by weight of a water-soluble polyethylene glycol which is meltable at body temperature, and the foaming agent comprising about 10 to 20 percent by weight of a mixture of tartaric acid and sodium bicarbonate, and a method of producing the same, are disclosed.

I claim: 
     
       1. In a spermicidally active vaginal suppository consisting essentially of spermicide, a suppository base comprising a water-soluble polyethylene glycol, foaming agent, and foam-stabilizing agent, wherein the spermicide is an alkylphenoxypolyethoxyethanol, the improvement which comprises (1) the employment of about 65 to 85 percent by weight of a water-soluble polyethylene glycol which is meltable at body temperature as the suppository base and (2) about 10 to 20 percent by weight of a mixture of tartaric acid and sodium bicarbonate as the foaming agent. 
     
     
       2. A spermicidally active vaginal suppository according to claim 1 consisting essentially of about 2 to 5 percent by weight of p-nonylphenoxypolyethoxyethanol, about 65 to 85 percent by weight of water-soluble polyethylene glycol meltable at body temperature, about 10 to 20 percent by weight of a mixture of tartaric acid and sodium bicarbonate, and about 2 to 4 percent by weight to sodium lauryl sulfate. 
     
     
       3. A spermidically active vaginal suppository according to claim 2 consisting essentially of 2 to 5 percent by weight of p-nonylphenoxypolyethoxyethanol, 65 to 85 percent by weight of a mixture of polyethylene glycol of a molecular weight of about 1350 and polyethylene glycol of a molecular weight of about 1000, 10 to 20 percent by weight of a mixture of tartaric acid and sodium hydrogen carbonate, and 2 to 4 percent by weight of sodium lauryl sulfate. 
     
     
       4. A spermicidally active suppository according to claim 2 having an egg-shaped form and a weight of between 2 to 5 grams and consisting essentially of 2 to 5 percent by weight of p-nonylphenoxypolyethoxyethanol, 65 to 85 percent by weight of a mixture of polyethylene glycol of a molecular weight of about 1350 and polyethylene glycol of a molecular weight of about 1000, 10 to 20 percent by weight of a mixture of tartaric acid and sodium bicarbonate, and 2 to 4 percent by weight of sodium lauryl sulfate. .Iadd. 5. In a spermicidally active vaginal suppository consisting essentially of spermicide, a suppository base comprising a water-soluble polyethylene glycol, foaming agent, and foam-stabilizing agent, wherein the spermicide is an alkylphenoxypolyethoxyethanol, the improvement which comprises (1) the employment of about 65 to 85 percent by weight of a water-soluble polyethylene glycol which is meltable at body temperature as the suppository base and (2) about 10 to 20 percent by weight of a mixture of an organic acid selected from the group consisting of tartaric acid, sodium hydrogen tartaric acid, succinic acid, and citric acid, together with a member selected from the group consisting of sodium bicarbonate and 
     
     
        carbonate glycine sodium, as foaming agent. .Iaddend..Iadd. 6. In a spermicidally active vaginal suppository consisting essentially of spermicide, a suppository base comprising a water-soluble polyethylene glycol, foaming agent, and foam-stabilizing agent, wherein the spermicide is an alkylphenoxypolyethoxyethanol, the improvement which comprises (1) the employment of about 65 to 85 percent by weight of a water-soluble polyethylene glycol which is meltable at body temperature as the suppository base and (2) about 10 to 20 percent by weight of a mixture of a water-soluble organic acid which is solid at room temperature and a member of the group consisting of an alkaline carbonate, alkaline bicarbonate, alkaline earth carbonate, and alkaline earth bicarbonate, as foaming agent. .Iaddend. .Iadd. 7. In a suppository base comprising a water-soluble polyethylene glycol, foaming agent, and foam-stabilizing agent, the improvement which comprises (1) the employment of about 65 to 85 percent by weight of a water-soluble polyethylene glycol which is meltable at body temperature as the suppository base and (2) about 10 to 20 percent by weight of a mixture of tartaric acid and sodium bicarbonate as the foaming agent. .Iaddend..Iadd. 8. A suppository base according to claim 7 consisting essentially of about 65 to 85 percent by weight of water-soluble polyethylene glycol meltable at body temperature, about 10 to 20 percent by weight of a mixture of tartaric acid and sodium bicarbonate, and about 2 to 4 percent by weight of sodium lauryl sulfate. .Iaddend..Iadd. 9. A suppository base according to claim 8 consisting essentially of 65 to 85 percent by weight of a mixture of polyethylene glycol of a molecular weight of about 1350 and polyethylene glycol of a molecular weight of about 1000, 10 to 20 percent by weight of a mixture of tartaric acid and sodium hydrogen carbonate, and 2 to 4 percent by weight of sodium lauryl sulfate. .Iaddend..Iadd. 10. A suppository base according to claim 8 having an egg-shaped form and a weight of between 2 to 5 grams and consisting essentially of 65 to 85 percent by weight of a mixture of polyethylene glycol of a molecular weight of about 1350 and polyethylene glycol of a molecular weight of about 1000, 10 to 20 percent by weight of a mixture of tartaric acid and sodium bicarbonate, and 2 to 4 percent by weight of sodium lauryl sulfate. .Iaddend. .Iadd. 11. In a suppository base comprising a water-soluble polyethylene glycol, foaming agent, and foam-stabilizing agent, the improvement which comprises (1) the employment of about 65 to 85 percent by weight of a water-soluble polyethylene glycol which is meltable at body temperature as the suppository base and (2) about 10 to 20 percent by weight of a mixture of an organic acid selected from the group consisting of tartaric acid, sodium hydrogen tartaric acid, succinic acid, the citric acid, together with a member selected from the group consisting of sodium bicarbonate and carbonate glycine sodium, as foaming agent. .Iaddend..Iadd. 12. In a suppository base comprising a water-soluble polyethylene glycol, foaming agent, and foam-stabilizing agent, the improvement which comprises (1) the employment of about 65 to 85 percent by weight of a water-soluble polyethylene glycol which is meltable at body temperature as the suppository base and (2) about 10 to 20 percent by weight of a mixture of a water-soluble organic acid which is solid at room temperature and a member of the group consisting of an alkaline carbonate, alkaline bicarbonate, alkaline earth carbonate, and alkaline earth bicarbonate, as foaming agent. .Iaddend.