USRE29076EExpiredUtility
Tablet formulation
Priority: Dec 4, 1974Filed: Mar 15, 1976Granted: Dec 14, 1976
Est. expiryDec 4, 1994(expired)· nominal 20-yr term from priority
A61K 9/2072A61J 3/10
4
PatentIndex Score
1
Cited by
15
References
9
Claims
Abstract
The disclosure is directed to formulations for tablets which are to be deeply grooved to facilitate breaking into predetermined portions by the user. A critical tablet weight for deeply grooved tablets is disclosed.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1. A chewable pharmaceutical tablet which is adequately imprinted with indicia or embossing and scored to form a groove which is 1/3 to 2/3 the depth of the total tablet thickness to facilitate separation into subdivisions containing substantially equal amounts of pharmaceutically active ingredient comprising a directly compressed formulation of: ______________________________________
A. Active ingredient 5 to 10 milligrams
B. Microcrystalline Cellulose
20 to 25 percent
by weight
C. Dextrose and corn syrup
30 to 55 percent
solids granulation by weight
D. Mannitol 20 to 30 percent
by weight
E. Magnesium stearate 0.9 to 1.0 percent - by weight -F. The
remainder being
pharmaceutically acceptable
fillers, extenders, flavoring
and the like.
______________________________________
2. A tablet as defined in claim 1 in which the ingredients are present in the following amounts: ______________________________________
A. Microcrystalline cellulose
20 percent by
weight
B. Dextrose and corn syrup
31.5 percent by
solids granulation weight
C. Mannitol 25 percent by
weight
D. Magnesium stearate 1 percent by weight
______________________________________
3. A tablet as defined in claim 1 in which the total tablet weight is 150 to 175 milligrams.
4. A tablet as defined in claim 1 in which the total tablet weight is about 175 milligrams.
5. A tablet as defined in claim 1 in which the active ingredient is 10 milligrams of isosorbide dinitrate.
6. A chewable pharmaceutical tablet which is deeply adequately imprinted with indicia or embossing and scored to form a groove which is 1/3 to 2/3 the depth of the total tablet thickness to facilitate separation into subdivisions containing substantially equal amount of a pharmaceutically active ingredient comprising a directly compressed formulation of: ______________________________________
A. Active ingredient 5 to 10 milligrams
B. Microcrystalline Cellulose
20 to 25 percent
by weight
C. Dextrose and corn syrup solids
50 to 55 percent
granulation by weight
D. Magnesium stearate 0.35 to 0.4 per-
cent by weight
E. Pharmaceutically acceptable
remainder
fillers, extenders, flavoring
and the like.
______________________________________
7. A tablet as defined in claim 6 in which the total tablet weight is 150 to 175 milligrams.
8. A tablet as defined in claim 6 in which the total tablet weight is 175 milligrams.
9. A tablet as defined in claim 6 in which the active ingredient is 10 milligrams of isosorbide dinitrate. .Iadd. 10. A chewable pharmaceutical tablet which is adequately imprinted with indicia or embossing and scored to form a groove which is 1/3 to 2/3 the depth of the total tablet thickness to facilitate separation into subdivisions containing substantially equal amounts of pharmaceutically active ingredient comprising a directly compressed formulation of an effective amount of an active ingredient and: ______________________________________
.Iadd.A..Iaddend.
.Iadd.Microcrystalline Cellulose.Iaddend.
.Iadd.20 to 25 percent by weight.Iaddend.
.Iadd.B..Iaddend.
.Iadd.Dextrose and corn syrup.Iaddend.
.Iadd.30 to 55 percent by weight.Iaddend.
.Iadd.solids granulation.Iaddend.
.Iadd.C..Iaddend.
.Iadd.Mannitol.Iaddend.
.Iadd.20 to 30 percent by weight.Iaddend.
.Iadd.D..Iaddend.
.Iadd.Magnesium stearate.Iaddend.
.Iadd.0.9 to 1.0 percent by.Iaddend.
.Iadd.weight.Iaddend.
.Iadd.E..Iaddend.
.Iadd.The remainder being.Iaddend.
.Iadd.pharmaceutically acceptable.Iaddend.
.Iadd.fillers, extenders, flavoring.Iaddend.
.Iadd.and the like..Iaddend.
______________________________________
.Iadd. 11. A chewable pharmaceutical tablet which is deeply adequately
imprinted with indicia or embossing and scored to form a groove which is
1/3 to 2/3 the depth of the total tablet thickness to facilitate
separation into subdivisions containing substantially equal amounts of a
pharmaceutically active ingredient comprising a directly compressed
formulation of an effective amount of an active ingredient and:
______________________________________
.Iadd.A..Iaddend.
.Iadd.Microcrystalline Cellulose.Iaddend.
.Iadd.20 to 25 percent by weight.Iaddend.
.Iadd.B..Iaddend.
.Iadd.Dextrose and corn syrup.Iaddend.
.Iadd.50 to 55 percent by weight.Iaddend.
.Iadd.solids granulation.Iaddend.
.Iadd.C..Iaddend.
.Iadd.Magnesium stearate.Iaddend.
.Iadd.0.35 to 0.4 percent by weight.Iaddend.
.Iadd.D..Iaddend.
.Iadd.Pharmaceutically.Iaddend.
.Iadd.remainder.Iaddend.
.Iadd.acceptable fillers,.Iaddend.
.Iadd.extenders, flavoring.Iaddend.
.Iadd.and the like..Iaddend.
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