Crystalline p-hydroxyampicillin and salts thereof

Abstract

Derivatives of 6-Aminopenicillanic Acid possessing antibacterial activity are disclosed.

We claim:  .[.1. A compound selected from the group consisting of 6-[(-)-α-amino-p-hydroxyphenylacetamido]-penicillanic acid and the non-toxic, pharmaceutically acceptable acid addition and base addition salts thereof and salts with non-toxic amines..]. .[.2. A compound or salt according to claim 1 which is amorphous or crystalline in form..]. .[.3. A compound or salt according to claim 1 which is anhydrous or hydrated..]. .[.4. A compound or salt according to claim 1 which is free of traces of high molecular weight allergenic impurities..]. .[.5. A compound or salt according to claim 1, wherein the salt is selected from the group consisting of the hydrochloric, phosphoric, sulfuric, thiocyanic and β-naphthalene sulfonic acids and the sodium and potassium alkali metal salts..]..Iadd. 6. Crystalline 6-(-)-α-amino-p-hydroxyphenylacetamido]-penicillanic acid trihydrate. .Iaddend. .Iadd. 7. Crystalline 6-[(-)-α-amino-p-hydroxyphenylacetamido] penicillanic acid hydrochloride trihydrate. .Iaddend..Iadd. 8. Crystalline di-(6-[(-)-α-amino-p-hydroxyphenylacetamido] penicillanic acid) sulphate. .Iaddend..Iadd. 9. Crystalline 6-[(-)-α-amino-α-(p-hydroxyphenyl)acetamido] penicillanic acid β-naphthalenesulphonate trihydrate. .Iaddend.