Antibiotic X-5108 for stimulating growth

Abstract

A new antibiotic, designated as antibiotic X-5108, is produced by a new species of streptomyces. The new antibiotic is active against gram-positive and gram-negative bacteria and produces growth stimulation and increased feed efficiency in poultry..Iadd.

1. A composition for enhancing the feed efficiency and stimulating the growth of poultry which comprises antibiotic X-5108, a yellow amorphous substance characterized as follows: (a) analysis: carbon, 63.63%; hydrogen, 7.81%; nitrogen, 3.48%; oxygen, 25.08% (by difference);   (b) soluble in methanol, ethanol, 1- and 2-propanol, tert. butyl alcohol, ethyl acetate, amyl acetate, butyl acetate and chloroform;   (c) a characteristic infrared absorption spectrum as shown in accompanying FIG. 1;   (d) a characteristic nuclear magnetic resonance spectrum as shown in accompanying FIG. 4; or a pharmaceutically acceptable salt thereof, and a non-toxic inert ingredient, wherein antibiotic X-5108 or a salt thereof is present in a ratio by weight of from about 0.0001 part to about 0.01 part per 100 parts     
     
     
       2. The composition of claim 1 wherein said non-toxic inert ingredient is a high energy nutrient feed for poultry containing a carbohydrate source and 
     
     
       3. The composition of claim 1 wherein an alkali metal salt of antibiotic 
     
     
       4. A composition for enhancing the feed efficiency and stimulating the growth of poultry which comprises a concentrated pre-mixture of antibiotic X-5108, said antibiotic being a yellow amorphous substance characterized as follows: (a) analysis: carbon, 63.63%; hydrogen, 7.71%; nitrogen, 3.48%; oxygen, 25.08% (by difference);   (b) soluble in methanol, ethanol, 1- and 2-propanol, tert. butyl alcohol, ethyl acetate, amyl acetate, butyl acetate and chloroform;   (c) a characteristic infrared absorption spectrum as shown in accompanying FIG. 1;   (d) a characteristic nuclear magnetic resonance spectrum as shown in accompanying FIG. 4; or a pharmaceutically acceptable salt thereof, and an inert, non-toxic ingredient wherein said pre-mixture upon addition to a coventional poultry feed containing a protein source and a carbohydrate source, produces a feed containing per 100 parts by weight of feed from about 0.0001 to about 0.01 part by weight of antibiotic X-5108 or a pharmaceutically acceptable     
     
     
       5. A method for stimulating the growth and enhancing the feed efficiency of poultry which comprises orally administering to poultry as their regular feed requirement a composition containing antibiotic X-5108, a yellow amorphous substance characterized as follows: (a) analysis: carbon, 63.63%; hydrogen, 7.81%; nitrogen, 3.48%; oxygen, 25.08% (by difference);   (b) soluble in methanol, ethanol, 1- and 2-propanol, tert. butyl alcohol, ethyl acetate, amyl acetate, butyl acetate and chloroform;   (c) a characteristic infrared absorption spectrum as shown in accompanying FIG. 1;   (d) a characteristic nuclear magnetic resonance spectrum as shown in accompanying FIG. 4; or a pharmaceutically acceptable salt thereof, and a high energy nutrient feed for poultry containing a carbohydrate source and a protein source, wherein said antibiotic X-5108 or said salt thereof is present in a ratio by weight of from about 0.0001 part to about 0.01 part of antibiotic X-5108 or a salt thereof per 100 parts feed.