US9949919B2ActiveUtilityA1
Stable, non-irritating topical formulations of hydroquinone
Est. expiryFeb 27, 2033(~6.6 yrs left)· nominal 20-yr term from priority
A61K 8/64A61K 2800/75A61K 8/4946A61K 8/675A61Q 19/00A61K 8/9789A61K 8/347A61K 8/36A61K 8/602A61Q 19/02A61K 8/342A61K 8/9706A61K 8/494A61K 8/9794A61K 8/345A61K 8/42A61K 8/498A61K 8/97
70
PatentIndex Score
1
Cited by
7
References
12
Claims
Abstract
Described herein are methods and compositions for increasing the efficacy and decreasing the irritancy of topical formulations of hydroquinone.
Claims
exact text as granted — not AI-modifiedWe claim:
1. A method for decreasing the irritancy of a 1%-3% hydroquinone-containing formulation comprising adding an emollient and an anti-irritant to the formulation, wherein the formulation comprises an oil-in-water emulsion, thereby forming a less irritating hydroquinone-containing formulation, wherein the less irritating hydroquinone-containing formulations consists essentially of, by weight of the formulation
Purified Water
From about 30% to about 70%
Hydrofluorocarbon 227ea
From about 6% to about 18%
Pentylene Glycol
From about 3% to about 7%
Cyclomethicone
From about 3% to about 7%
Niacinamide
From about 2% to about 6%
Isononyl Isononoate
From about 1% to about 4%
C 12 -C 15 Alkyl Ethylhexanoate
From about 1% to about 4%
Glycerin
From about 1% to about 3%
Hydroquinone
From about 1% to about 3%
Alpha-Arbutin
From about 1% to about 3%
Dimethicone/Divinyldimethicone/
From about 1% to about 3%
Silsesquioxane Crosspolymer
Moringa Oleifera Seed Oil
From about 1% to about 3%
Glyceryl Stearate
From about 1% to about 3%
Cetyl Alcohol
From about 1% to about 3%
Dimethicone
From about 0.5% to about 1.5%
Cetearyl Alcohol
From about 0.5% to about 1.5%
Kojic Acid
From about 0.5% to about 1.5%
Panthenol
From about 0.5% to about 1.5%
1-Methylhydantoine-2-Imide
From about 0.5% to about 1.5%
Algae Extract and Mugwort
From about 0.5% to about 1.5%
( Artemisia vulgaris ) Extract
Magnesium Aluminum Silicate
From about 0.5% to about 1.5%
PEG- 75 Stearate
From about 0.5% to about 1.5%
Avena Sativa (Oat) Kernel Extract
From about 0.1% to about 1.0%
Saccharomyces/ Xylinum /Black Tea
From about 0.2% to about 0.6%
Ferment
Palmaria Palmata Extract
From about 0.1% to about 0.4%
Brassica Napus Extract
From about 0.3% to about 1.0%
Punica Granatum (Pomegranate)
From about 0.1% to about 0.4%
Seed Oil
Rubus Occidentalis (Black
From about 0.1% to about 0.4%
Raspberry) Seed Oil
Vaccinium Macrocarpon
From about 0.1% to about 0.4%
(Cranberry) Seed Oil
Citrullus Lanatus (Watermelon)
From about 0.01% to about 0.05%
Seed Oil
Rubus Idaeus (Raspberry) Seed Oil
From about 0.01% to about 0.05%
Salvia Hispanica (Chia) Seed Oil
From about 0.01% to about 0.05%
Tetrahexadecyl Ascorbate
From about 0.3% to about 0.7%
Ceteth-20
From about 0.2% to about 0.6%
Steareth-20
From about 0.2% to about 0.6%
Allantoin
From about 0.3% to about 0.7%
Chlorphenesin
From about 0.1% to about 0.4%
Hexapeptide-2
From about 0.1% to about 1.0%
Jojoba Esters
From about 0.1% to about 0.4%
Moringa Oil/Hydrogenated Moringa
From about 0.1% to about 0.4%
Oil Esters
Bisabolol
From about 0.1% to about 0.3%
Fragrance
From about 0.1% to about 0.3%
Sodium Bisulfite
From about 0.02% to about 0.07%
Sodium Sulfite
From about 0.02% to about 0.07%
Tocopheryl Acetate
From about 0.05% to about 0.15%
Xanthan Gum
From about 0.05% to about 0.15%
Citric Acid
From about 0.1% to about 0.3%
Potassium Sorbate
From about 0.1% to about 0.3%
Sodium Benzoate
From about 0.1% to about 0.3%
Dextran
From about 0.1% to about 1.0%
Sodium Hyaluronate
From about 0.005% to about 0.015%
BHT
From about 0.1% to about 0.3%
Stearyl Glycyrrhetinate
From about 0.05% to about 0.15%
Disodium EDTA
From about 0.05% to about 0.15%
Phenoxyethanol
From about 0.01% to about 0.10%
Hydroxvethylcellulose
From about 0.1% to about 1.0%
Glycyrrhiza Glabra (Licorice)
From about 0.02% to about 0.07%.
Root Extract
2. The method of claim 1 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of an affected subject, does not produce edema or erythema.
3. The method of claim 1 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of affected subjects, shows an average reported irritation no more than mild after 4 weeks.
4. The method of claim 1 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of affected subjects, no more than 20% of subjects report irritation after 4 weeks.
5. The method of claim 1 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of affected subjects, shows an average reported irritation no more than mild after 12 weeks.
6. The method of claim 1 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of affected subjects, no more than 16% of subjects report irritation after 12 weeks.
7. A method for decreasing the irritancy of a 1%-3% hydroquinone-containing formulation comprising adding an emollient and an anti-irritant to the formulation, wherein the formulation comprises an oil-in-water emulsion, thereby forming a less irritating hydroquinone-containing formulation, wherein the less irritating hydroquinone-containing formulations consists essentially of, by weight of the formulation
Purified Water
From about 30% to about 70%
Hydrofluorocarbon 227ea
From about 6% to about 18%
Pentylene Glycol
From about 3% to about 7%
Cyclomethicone
From about 1% to about 2%
Niacinamide
From about 2% to about 6%
Isononyl Isononoate
From about 1% to about 3%
C12-C15 Alkyl Ethylhexanoate
From about 1% to about 3%
Glycerin
From about 1% to about 3%
Hydroquinone
From about 1% to about 3%
Alpha-Arbutin
From about 1% to about 3%
Dimethicone/Divinyldimethicone/
From about 1% to about 3%
Silequioxane Crosspolymer
Glyceryl Stearate
From about 1% to about 3%
Cetyl Alcohol
From about 1% to about 3%
Dimethicone
From about 0.5% to about 1.5%
Cetearyl Alcohol
From about 0.5% to about 1.5%
Kojic Acid
From about 0.5% to about 1.5%
Panthenol
From about 0.5% to about 1.5%
1-Methylhydantoine-2-Imide
From about 0.5% to about 1.5%
Algae Extract and Mugwort
From about 0.5% to about 1.5%
( Artemisia vulgaris ) Extract
Magnesium Aluminum Silicate
From about 0.5% to about 1.5%
PEG- 75 Stearate
From about 0.5% to about 1.5%
Avena Sativa (Oat) Kernel Extract
From about 0.1% to about 1.0%
Saccharomyces / Xylinum /Black Tea
From about 1% to about 4%
Ferment
Palmaria Palmata Extract
From about 0.1% to about 0.5%
Brassica Napus Extract
From about 0.04% to about 0.1%
Punica Granatum (Pomegranate)
From about 0.3% to about 0.9%
Seed Oil
Rubus Occidentalis (Black
From about 0.3% to about 0.9%
Raspberry) Seed Oil
Vaccinium Macrocarpon
From about 0.3% to about 0.9%
(Cranberry) Seed Oil
Citrullus Lanatus (Watermelon)
From about 0.06% to about 0.13%
Seed Oil
Rubus Idaeus (Raspberry) Seed Oil
From about 0.06% to about 0.13%
Salvia Hispanica (Chia) Seed Oil
From about 0.06% to about 0.13%
Tetrahexadecyl Ascorbate
From about 0.2% to about 0.7%
Ceteth-20
From about 0.1% to about 0.5%
Steareth-20
From about 0.1% to about 0.5%
Allantoin
From about 0.2% to about 0.7%
Chlorphenesin
From about 0.1% to about 0.5%
Hexapeptide-2
From about 0.1% to about 1.0%
Bisabolol
From about 0.1% to about 0.3%
Fragrance
From about 0.1% to about 0.3%
Sodium Bisulfite
From about 0.02% to about 0.07%
Sodium Sulfite
From about 0.02% to about 0.07%
Tocopheryl Acetate
From about 0.2% to about 0.7%
Xanthan Gum
From about 0.05% to about 0.15%
Citric Acid
From about 0.05% to about 0.20%
Potassium Sorbate
From about 0.05% to about 0.20%
Sodium Benzoate
From about 0.05% to about 0.20%
Dextran
From about 0.1% to about 1.0%
Sodium Hyaluronate
From about 0.005% to about 0.015%
BHT
From about 0.1% to about 0.3%
Stearyl Glycyrrhetinate
From about 0.05% to about 0.15%
Disodium EDTA
From about 0.05% to about 0.15%
Phenoxyethanol
From about 0.05% to about 0.1%
Hydroxyethylcellulose
From about 0.1% to about 1.0%
Glycyrrhiza Glabra (Licorice)
From about 0.02% to about 0.07%
Root Extract
Acacia Decurrens /Jojoba/
From about 1% to about 3%
Sunflower Seed Wax Polyceryl-3
Esters
Butyrospermum Parkii (Shea)
From about 1% to about 3%.
Butter
8. The method of claim 7 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of an affected subject, does not produce edema or erythema.
9. The method of claim 7 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of affected subjects, shows an average reported irritation no more than mild after 4 weeks.
10. The method of claim 7 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of affected subjects, no more than 20% of subjects report irritation after 4 weeks.
11. The method of claim 7 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of affected subjects, shows an average reported irritation no more than mild after 12 weeks.
12. The method of claim 7 , wherein the less irritating hydroquinone-containing formulation, upon application to the skin of affected subjects, no more than 16% of subjects report irritation after 12 weeks.Join the waitlist — get patent alerts
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