NF-κB inhibitor composition for skin health

Abstract

A novel NF-κB-inhibitor peptide is a component in a skin care composition comprising the NF-κB-inhibitor and a dermatologically acceptable carrier. The composition may also include at least one additional skin care active. Additionally, the composition may include a peptide that acts as a TGF-β1 mimic. Means for treating mature, languished skin with compositions comprising the peptide are also provided.

What is claimed is: 
     
       1. A cosmetic composition, comprising: at least two components, one component being an NF-κB-inhibitor peptide having the sequence N-M-A-N-A-K (SEQ ID NO: 1); and a dermatologically acceptable carrier. 
     
     
       2. The cosmetic composition as in  claim 1  wherein the NF-κB-inhibitor peptide is present in an amount effective to inhibit NF-κB activity. 
     
     
       3. The composition as in  claim 2  wherein an additional component is a TGF-β mimic. 
     
     
       4. The composition as in  claim 3  wherein the TGF-β mimic is a peptide having the sequence A-N-V-A-E-N-A (SEQ ID NO: 2). 
     
     
       5. The composition as in  claim 1  wherein the carrier is suitable for topical administration. 
     
     
       6. A method of inhibiting NF-κB activity, comprising: administering to the skin of a patient in need thereof, an effective amount of the cosmetic composition of  claim 1 . 
     
     
       7. The method as in  claim 6  wherein the cosmetic composition of  claim 1  is effective in negating mammalian skin maladies and signs of aging skin. 
     
     
       8. The method as in  claim 7  wherein said maladies comprise blemishes, lesions, pimples, pre-emergent pimples, blackheads, and/or whiteheads. 
     
     
       9. The method as in  claim 7  wherein said signs of aging comprise the need of improvement in firmness or texture, the appearance of lines or wrinkles, or the loss of elasticity. 
     
     
       10. A method of treating skin maladies and signs of aging skin of the skin of a mammal in need thereof, comprising applying to said skin the cosmetic composition according to  claim 3 . 
     
     
       11. The method as in  claim 10  wherein the TGF-β mimic reduces inflammation of said skin. 
     
     
       12. The method as in  claim 10  wherein the NF-κB-inhibitor peptide has the sequence N-M-A-N-A-K (SEQ ID NO: 1). 
     
     
       13. The method as in  claim 10  wherein the TGF-β mimic is a peptide having the sequence A-N-V-A-E-N-A (SEQ ID NO: 2). 
     
     
       14. The method as in  claim 10  wherein said maladies comprise blemishes, lesions, pimples, pre-emergent pimples, blackheads, and/or whiteheads. 
     
     
       15. The method as in  claim 10  wherein said signs of aging comprise the need of improvement in firmness or texture, the appearance of lines or wrinkles, or the loss of elasticity.