US9878054B2ActiveUtilityA1

Polypeptide and lipophilic moiety conjugate compositions, formulations, and uses related thereto

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Assignee: TUFTS MEDICAL CT INCPriority: May 18, 2012Filed: May 17, 2013Granted: Jan 30, 2018
Est. expiryMay 18, 2032(~5.8 yrs left)· nominal 20-yr term from priority
Inventors:Athan Kuliopulos
C07K 14/705A61K 47/6907A61K 47/542A61K 47/26A61K 38/177A61K 9/19A61K 9/1075A61K 9/0019A61K 47/64A61K 47/545A61K 47/543A61K 47/62A61K 38/08A61K 45/06A61K 47/48046A61K 47/48038A61K 47/48238A61K 47/488
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References
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Claims

Abstract

In certain embodiments, this disclosure relates to pharmaceutical formulations for polypeptide and lipophilic moiety conjugates suitable for injection into humans and other animals and methods of preparation. In certain embodiments, the disclosure relates to a method of preparing the formulation comprising lyophilizing, solubilizing in ammonium acetate, filtering to create mono-disperse particles, re-lyophilizing, and solubilizing the micelles in a dextrose solution for injection.

Claims

exact text as granted — not AI-modified
What I claim: 
     
       1. A pharmaceutical composition comprising micelles of palmitate-KKSRALF-NH 2  (palmitate-SEQ ID NO:2-NH 2 ) acid salts and an aqueous solution comprising dextrose at about 5% by weight. 
     
     
       2. The pharmaceutical composition of  claim 1 , wherein the palmitate-KKSRALF-NH 2  acid salts are in the form of acetic acid salts.

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