Packaged product of solid preparation containing 5-hydroxy-1H-imidazole-4-carboxamide or salt thereof, or hydrate thereof

Abstract

The present invention provides a packaged product of a solid preparation containing 5-hydroxy-1H-imidazole-4-carboxamide or a salt thereof, or a hydrate thereof, which comprises the solid preparation and an environment-controlling agent packaged together. The packaged product of present invention is useful as a packaged product of a solid preparation containing 5-hydroxy-1H-imidazole-4-carboxamide or a salt thereof, or a hydrate thereof, with which discoloration of the solid preparation is suppressed, and superior storage stability of the solid preparation is obtained.

The invention claimed is: 
     
       1. A packaged product of a solid preparation containing
 5-hydroxy-1H-imidazole-4-carboxamide or a salt thereof, or a hydrate thereof, which comprises the solid preparation and an environment-controlling agent packaged together, 
 wherein the environment-controlling agent is a deoxidant that exhibits a deoxidation function in a dry atmosphere, wherein the deoxidant is PHARMAKEEP KH, and 
 the packaged product further contains a desiccant. 
 
     
     
       2. The packaged product of the solid preparation according to  claim 1 , wherein the packaged product further contains a self-activating type deoxidant. 
     
     
       3. A method for stabilizing a solid preparation containing 5-hydroxy-1H-imidazole-4-carboxamide or a salt thereof, or a hydrate thereof, which comprises packaging the solid preparation together with an environment-controlling agent, wherein the environment-controlling agent is a deoxidant that exhibits a deoxidation function in a dry atmosphere, wherein the deoxidant is PHARMAKEEP KH, and the packaged product further contains a desiccant. 
     
     
       4. The method for stabilizing a solid preparation according to  claim 3 , wherein a self-activating type deoxidant is further packaged together. 
     
     
       5. The packaged product of the solid preparation according to  claim 1 , wherein the solid preparation is stable after storage for four weeks under conditions of 60° C. 
     
     
       6. The packaged product of the solid preparation according to  claim 1 , wherein the solid preparation is stable after storage for three months under conditions of 40° C. 
     
     
       7. The packaged product of the solid preparation according to  claim 1 , wherein the deoxidant is PHARMAKEEP KH-20. 
     
     
       8. The method for stabilizing a solid preparation according to  claim 3 , wherein the deoxidant is PHARMAKEEP KH-20.